Reactive oxygen species (ROS) are oxygen derivates and play an active role in vascular
biology. These compounds are generated within the vascular wall, at the level of endothelial …

Reactive oxygen species are oxygen derivates and play an active role in vascular biology.
These compounds are generated within the vascular wall, at the level of endothelial and …

Since the landmark study on renovascular hypertension by Goldblatt et al in 1934, 1 it has
become clear that the RAS plays a major role in hypertension and other cardiovascular …

Infusion of ANG II at a rate not sufficient to evoke an immediate vasoconstrictor response,
produces a slow increase in blood pressure. Circulating levels of ANG II may be within …

1. Hypertension is associated with structural alterations of resistance arteries, a process
known as remodelling (increased media-to-lumen ratio). 2. At the cellular level, vascular …

HIROOKA Y et al. rats. In addition, superoxide dismutase (SOD) expression and activity,
which are ROS scavenging factors, were decreased in the RVLM of SHRSP compared with …

The renin–angiotensin system (RAS) is involved in the pathological mechanisms of target
organ damage, as well as in the induction of hypertension. RAS inhibition by angiotensin …

The development of essential hypertension involves several factors. Vascular dysfunction,
characterized by endothelial dysfunction, low-grade inflammation and structural remodeling …

The concept of hypertension as primarily a consequence of altered hemodynamics has
changed. Many factors are now implicated in the development of hypertensive vascular …

Many factors have been implicated in the pathophysiology of hypertension such as
upregulation of the renin-angiotensin-aldosterone system, activation of the sympathetic …