[Frontiers in Bioscience 14, 5291-5338, June 1, 2009] 5291 Neurobiology of depression,
fibromyalgia and neuropathic pain Vladimi Page 1 [Frontiers in Bioscience 14, 5291-5338, June …

Fibromyalgia and depression might represent two manifestations of affective spectrum
disorder. They share similar pathophysiology and are largely targeted by the same drugs …

The increasing number of individuals with comorbidities poses an urgent need to improve
the management of patients with multiple co-existing diseases. Among these comorbidities …

This article examines the biological, genetic, and environmental aspects of fibromyalgia that
may have an impact on its pathogenesis. Symptoms of fibromyalgia may be related to …

Genetic and environmental factors may play a role in the etiopathology of fibromyalgia
syndrome (FMS) and other related syndromes. There is a high aggregation of FMS in …

Remarkable progresses have been achieved regarding the understanding of the
neurobiological bases of pain and depression. The principal role of neurotransmitters …

The prevalence of pain in depressed individuals and the prevalence of depression in
patients with pain are higher than when these conditions are considered individually. When …

Chronic pain states are common in the general population. Genetic factors can explain a
significant amount of the variability in the perception of pain. Fibromyalgia syndrome (FMS) …

Fibromyalgia is characterized by widespread pain and tenderness, and has a significant
familial component. The etiology of fibromyalgia remains unclear, but genetic factors seem …

Objectives. To review the literature addressing the relationship between mood disorders and
fibromyalgia/chronic pain and our current understanding of overlapping pathophysiological …