Objectives Appropriate antibiotic exposure at the site of infection is important for clinically
effective therapy. This study compared the epithelial lining fluid (ELF) penetration of …

A comprehensive review of drug penetration into pulmonary epithelial lining fluid (ELF) was
previously published in 2011. Since then, an extensive number of studies comparing plasma …

Objectives Ceftolozane/tazobactam is approved for hospital-acquired/ventilator-associated
bacterial pneumonia at double the dose (ie 2 g/1 g) recommended for other indications. We …

Objective To determine the steady-state plasma and epithelial lining fluid (ELF)
concentrations of piperacillin/tazobactam (P/T) administered to critically ill patients with …

ABSTRACT WCK 5222 is a combination of cefepime and the novel β-lactam enhancer
zidebactam being developed for the treatment of serious Gram-negative bacterial infections …

Background Knowledge of antibiotic concentrations achievable in the epithelial lining fluid
(ELF) will help guide antibiotic dosing for treating patients with Gram-negative bacillary …

Ceftolozane/tazobactam is an antipseudomonal antibacterial approved for the treatment of
complicated urinary tract infections (cUTIs) and complicated intra‐abdominal infections …

The exposure-response relationship of anti-infective agents at the site of infection is
currently being re-examined. Epithelial lining fluid (ELF) has been suggested as the site …

Objectives The aim of this Phase 1, open-label study (NCT01395420) was to measure and
compare concentrations of ceftazidime and avibactam in bronchial epithelial lining fluid …

Objective To determine the steady-state plasma and epithelial lining fluid (ELF)
concentrations of ceftazidime administered in continuous infusion to critically ill patients with …