Advanced malignant melanoma has a poor prognosis since chemotherapy is mostly
ineffective due in part to the intrinsic and/or extrinsic resistance of melanoma cells to …

Malignant melanoma is considered to be a chemotherapy-refractory tumour and the
commonly used anticancer drugs do not seem to modify the prognosis of metastatic disease …

Melanoma is the most aggressive form of skin cancer and is notoriously resistant to all
current modalities of cancer therapy. A large set of genetic, functional and biochemical …

Metastatic melanomas are often resistant to chemotherapy. To study whether the p53
mutational status affects chemosensitivity, we compared the responses to chemotherapy of …

Most anticancer agents mediate their effects through common pathways which induce
apoptosis or in some cases necrosis of cancer cells. The apoptotic pathways are regulated …

Melanoma is the most aggressive form of skin cancer and advanced stages are inevitably
resistant to conventional therapeutic agents. In particular, the inability of undergo apoptosis …

Melanoma is a most dangerous and deadly type of skin cancer, and considered intrinsically
resistant to both radiotherapy and chemotherapy. It has become a major public health …

Apoptosis and necrosis are two morphologically distinct forms of cell death that are
important for maintaining of cellular homeostasis. Almost all agents can provoke either …

The increased incidence of malignant melanoma in the last decades, its high mortality and
pronounced therapy resistance pose an enormous challenge. Important therapeutic targets …

Anticancer drugs kill susceptible cells through induction of apoptosis. Alterations of apoptotic
pathways in drug-resistant tumor cells leading to apoptosis deficiency might represent a …