Multiple sclerosis (MS) is a complex chronic immune-mediated disease of the central
nervous system, affecting approximately 1 in 1000 individuals in Europe and the US866 …

Cells of hematopoietic origin express high levels of the immunoproteasome, a cytokine‐
inducible proteasome variant comprising the proteolytic subunits LMP2 (β1i), MECL‐1 (β2i) …

The proteasome is a multicatalytic enzyme expressed in all eukaryotic cells and responsible
for the degradation of polyubiquitinated proteins. Thereby, the proteasome regulates protein …

Numerous cellular processes are controlled by the proteasome, a multicatalytic protease in
the cytosol and nucleus of all eukaryotic cells, through regulated protein degradation. The …

The immunoproteasome, a special class of the proteasome, is mainly expressed in cells of
haematopoietic origin. Additionally, during inflammation, the immunoproteasome is induced …

The ubiquitin‐proteasome system is the major intracellular molecular machinery for protein
degradation and maintenance of protein homeostasis in most human cells. As ubiquitin …

The proteasome is a multicatalytic system involved in the degradation of polyubiquitinated
proteins. Thus, the proteasome is key to maintaining cell homeostasis. Stress and pro …

The 20S immunoproteasome (IP) is an interferon (IFN)-γ− and tumor necrosis factor (TNF)−
inducible variant of the 20S constitutive proteasome (CP) in which all its peptidolytically …

Treatment of cells with interferon-γ leads to the replacement of the constitutive catalytic
proteasome subunits β1, β2, and β5 by the inducible subunits LMP2 (β1i), MECL-1 (β2i) …

Selective inhibitors for the human immunoproteasome LMP7 (β5i) subunit over the
constitutive proteasome hold promise for the treatment of autoimmune and inflammatory …