Pulmonary hypertension (PH) is a group of syndromes characterized by irreversible vascular
remodeling and persistent elevation of pulmonary vascular resistance and pressure, leading …

EPAS1 (endothelial PAS domain protein 1), as the major effect gene for the adaptation to
chronic hypoxia, is required for hypoxic pulmonary hypertension (HPH). Downregulated …

Pulmonary arterial hypertension (PAH) is a life‐threatening disease featured with elevated
pulmonary vascular resistance and progressive pulmonary vascular remodelling. It has …

Objectives HIF2α is of vital importance in the regulation of endothelial dysfunction, cell
proliferation, migration, and pulmonary vascular remodeling in pulmonary hypertension. Our …

Pulmonary arterial hypertension (PAH) is characterized by endothelial dysfunction and
structural remodeling of the pulmonary vasculature, mediated initially by reduced oxygen …

Pulmonary vascular remodeling caused by the excessive proliferation of pulmonary arterial
smooth muscle cells (PASMCs) is the hallmark feature of pulmonary arterial hypertension …

Pulmonary arterial hypertension (PAH) is a debilitating progressive disease characterized
by excessive pulmonary vasoconstriction and abnormal vascular remodeling processes that …

Pulmonary hypertension (PH) is a life‐threatening lung disorder with towering prevalence
and risk for future has been gradually rising worldwide. Even, no specific medications are …

Pulmonary arterial hypertension (PAH) is a severe cardiovascular disorder with high
mortality. Multiple clinical diseases can induce PAH, but the underlying molecular …

Angiotensin-converting enzyme (ACE) enhances the proliferation and migration of
pulmonary artery smooth muscle cells (PASMCs), which contribute to the pathogenesis of …