Updated perspective of EPAS1 and the role in pulmonary hypertension
N Wang, J Hua, Y Fu, J An, X Chen, C Wang… - Frontiers in Cell and …, 2023 - frontiersin.org
Pulmonary hypertension (PH) is a group of syndromes characterized by irreversible vascular
remodeling and persistent elevation of pulmonary vascular resistance and pressure, leading …
remodeling and persistent elevation of pulmonary vascular resistance and pressure, leading …
EPAS1 (endothelial PAS domain protein 1) orchestrates transactivation of endothelial ICAM1 (intercellular adhesion molecule 1) by small nucleolar RNA host gene 5 …
S Wang, Y Wang, C Liu, G Xu, W Gao, J Hao… - …, 2021 - Am Heart Assoc
EPAS1 (endothelial PAS domain protein 1), as the major effect gene for the adaptation to
chronic hypoxia, is required for hypoxic pulmonary hypertension (HPH). Downregulated …
chronic hypoxia, is required for hypoxic pulmonary hypertension (HPH). Downregulated …
LncRNA PAXIP1‐AS1 fosters the pathogenesis of pulmonary arterial hypertension via ETS1/WIPF1/RhoA axis
R Song, S Lei, S Yang, SJ Wu - Journal of Cellular and …, 2021 - Wiley Online Library
Pulmonary arterial hypertension (PAH) is a life‐threatening disease featured with elevated
pulmonary vascular resistance and progressive pulmonary vascular remodelling. It has …
pulmonary vascular resistance and progressive pulmonary vascular remodelling. It has …
Hypoxia-inducible factor 2-Alpha mediated gene sets differentiate pulmonary arterial hypertension
J Zhu, L Zhao, Y Hu, G Cui, A Luo, C Bao… - Frontiers in Cell and …, 2021 - frontiersin.org
Objectives HIF2α is of vital importance in the regulation of endothelial dysfunction, cell
proliferation, migration, and pulmonary vascular remodeling in pulmonary hypertension. Our …
proliferation, migration, and pulmonary vascular remodeling in pulmonary hypertension. Our …
Expression and analyses of the HIF-1 pathway in the lungs of humans with pulmonary arterial hypertension
W Lei, Y He, X Shui, G Li, G Yan… - Molecular …, 2016 - spandidos-publications.com
Pulmonary arterial hypertension (PAH) is characterized by endothelial dysfunction and
structural remodeling of the pulmonary vasculature, mediated initially by reduced oxygen …
structural remodeling of the pulmonary vasculature, mediated initially by reduced oxygen …
Silencing EIF3A ameliorates pulmonary arterial hypertension through HDAC1 and PTEN/PI3K/AKT pathway in vitro and in vivo
HT Yang, G Wang, PC Zhu, ZY Xiao - Experimental Cell Research, 2023 - Elsevier
Pulmonary vascular remodeling caused by the excessive proliferation of pulmonary arterial
smooth muscle cells (PASMCs) is the hallmark feature of pulmonary arterial hypertension …
smooth muscle cells (PASMCs) is the hallmark feature of pulmonary arterial hypertension …
Angiotensin-Converting Enzyme 2 (ACE2) Signaling in Pulmonary Arterial Hypertension: Underpinning Mechanisms and Potential Targeting Strategies
KA Papavassiliou, VA Gogou… - International Journal of …, 2023 - mdpi.com
Pulmonary arterial hypertension (PAH) is a debilitating progressive disease characterized
by excessive pulmonary vasoconstriction and abnormal vascular remodeling processes that …
by excessive pulmonary vasoconstriction and abnormal vascular remodeling processes that …
Pulmonary hypertension: Molecular aspects of current therapeutic intervention and future direction
TK Arora, AK Arora, MK Sachdeva… - Journal of Cellular …, 2018 - Wiley Online Library
Pulmonary hypertension (PH) is a life‐threatening lung disorder with towering prevalence
and risk for future has been gradually rising worldwide. Even, no specific medications are …
and risk for future has been gradually rising worldwide. Even, no specific medications are …
Comparative transcriptional analysis of pulmonary arterial hypertension associated with three different diseases
W Wang, Z Jiang, D Zhang, L Fu, R Wan… - Frontiers in Cell and …, 2021 - frontiersin.org
Pulmonary arterial hypertension (PAH) is a severe cardiovascular disorder with high
mortality. Multiple clinical diseases can induce PAH, but the underlying molecular …
mortality. Multiple clinical diseases can induce PAH, but the underlying molecular …
Role of HIF-1α in the regulation ACE and ACE2 expression in hypoxic human pulmonary artery smooth muscle cells
R Zhang, Y Wu, M Zhao, C Liu, L Zhou… - … of Physiology-Lung …, 2009 - journals.physiology.org
Angiotensin-converting enzyme (ACE) enhances the proliferation and migration of
pulmonary artery smooth muscle cells (PASMCs), which contribute to the pathogenesis of …
pulmonary artery smooth muscle cells (PASMCs), which contribute to the pathogenesis of …