New perspectives in cancer biology from a study of canonical and non-canonical functions of base excision repair proteins with a focus on early steps
MC Malfatti, G Antoniali, M Codrich, S Burra… - …, 2020 - academic.oup.com
Alterations of DNA repair enzymes and consequential triggering of aberrant DNA damage
response (DDR) pathways are thought to play a pivotal role in genomic instabilities …
response (DDR) pathways are thought to play a pivotal role in genomic instabilities …
DNA base excision repair therapeutics: summary of targets with a focus on APE1
ML Fishel, C Vascotto, MR Kelley - DNA Repair and Cancer …, 2013 - api.taylorfrancis.com
The Base Excision Repair (BER) pathway is responsible for repairing some of DNA's most
prevalent lesions—those produced both endogenously and exogenously from alkylation …
prevalent lesions—those produced both endogenously and exogenously from alkylation …
Molecular mechanisms regulating the DNA repair protein APE1: a focus on its flexible N-terminal tail domain
DJ López, JA Rodríguez, S Bañuelos - International Journal of Molecular …, 2021 - mdpi.com
APE1 (DNA (apurinic/apyrimidinic site) endonuclease 1) is a key enzyme of one of the major
DNA repair routes, the BER (base excision repair) pathway. APE1 fulfils additional functions …
DNA repair routes, the BER (base excision repair) pathway. APE1 fulfils additional functions …
Transcriptional dysregulation of base excision repair proteins in breast cancer
G Wright, NR Gassman - DNA repair, 2020 - Elsevier
Base excision repair (BER) addresses the numerous base lesions and strand breaks
induced by exogenous and endogenous stressors daily. The complexity and importance of …
induced by exogenous and endogenous stressors daily. The complexity and importance of …
Posttranslational modification of mammalian AP endonuclease (APE1)
CS Busso, MW Lake, T Izumi - Cellular and molecular life sciences, 2010 - Springer
A key issue in studying mammalian DNA base excision repair is how its component proteins
respond to a plethora of cell-signaling mediators invoked by DNA damage and stress …
respond to a plethora of cell-signaling mediators invoked by DNA damage and stress …
Impairment of APE1 function enhances cellular sensitivity to clinically relevant alkylators and antimetabolites
Base excision repair (BER) is the major pathway for removing mutagenic and cytotoxic
oxidative and alkylation DNA modifications. Using a catalytically inactive, dominant negative …
oxidative and alkylation DNA modifications. Using a catalytically inactive, dominant negative …
Base excision repair: contribution to tumorigenesis and target in anticancer treatment paradigms
JL Illuzzi, DM Wilson III - Current medicinal chemistry, 2012 - ingentaconnect.com
Cancer treatments often lose their effectiveness due to the development of multiple drug
resistance. Thus, identification of key proteins involved in the tumorigenic process and the …
resistance. Thus, identification of key proteins involved in the tumorigenic process and the …
Tumor‐associated APE1 variant exhibits reduced complementation efficiency but does not promote cancer cell phenotypes
JL Illuzzi, DR McNeill, P Bastian… - Environmental and …, 2017 - Wiley Online Library
Base excision repair (BER) is the major pathway for coping with most forms of endogenous
DNA damage, and defects in the process have been associated with carcinogenesis …
DNA damage, and defects in the process have been associated with carcinogenesis …
Implications of DNA damage and DNA repair on human diseases
BC Nelson, M Dizdaroglu - Mutagenesis, 2020 - academic.oup.com
Cellular DNA damage is implicated in the aetiology and progression of many different types
of human disorders and diseases. Much of the current research in the DNA damage field is …
of human disorders and diseases. Much of the current research in the DNA damage field is …