Males and females have distinct molecular events in the articular cartilage during knee osteoarthritis

C Li, Z Zheng - International Journal of Molecular Sciences, 2021 - mdpi.com
Osteoarthritis (OA) is a major public health challenge that imposes a remarkable burden on
the affected individuals and the healthcare system. Based on the clinical observation, males …

Cartilage targets of knee osteoarthritis shared by both genders

C Li, Z Zheng - International Journal of Molecular Sciences, 2021 - mdpi.com
As the leading cause of disability, osteoarthritis (OA) affects people of all ages, sexes, and
races. With the increasing understanding of OA, the sex differences have attracted specific …

Identification of key genes and pathways associated with sex differences in osteoarthritis based on bioinformatics analysis

S Wang, H Wang, W Liu, B Wei - BioMed research international, 2019 - Wiley Online Library
Sex differences have been suggested to play critical roles in the pathophysiology of
osteoarthritis (OA), resulting in sex‐specific prevalence and incidence. However, their roles …

Gender-related aspects in osteoarthritis development and progression: a review

M Peshkova, A Lychagin, M Lipina, B Di Matteo… - International Journal of …, 2022 - mdpi.com
Osteoarthritis (OA) is a common degenerative joint disease treated mostly symptomatically
before approaching its definitive treatment, joint arthroplasty. The rapidly growing …

Molecular crosstalk between articular cartilage, meniscus, synovium, and subchondral bone in osteoarthritis

M Wang, G Tan, H Jiang, A Liu, R Wu, J Li… - Bone & Joint …, 2022 - boneandjoint.org.uk
Aims Osteoarthritis (OA) is a common degenerative joint disease worldwide, which is
characterized by articular cartilage lesions. With more understanding of the disease, OA is …

Reasons for the sex bias in osteoarthritis research: a review of preclinical studies

M Franke, C Mancino, F Taraballi - International Journal of Molecular …, 2023 - mdpi.com
Osteoarthritis (OA) is one of the most common degenerative diseases of articular cartilage.
During OA, all the elements that contribute to the joint undergo physiological and structural …

[HTML][HTML] Sex differences in osteoarthritis pathogenesis: a comprehensive study based on bioinformatics

Y Yang, X You, JD Cohen, H Zhou, W He… - … Medical Journal of …, 2020 - ncbi.nlm.nih.gov
Background Osteoarthritis (OA) is a common disorder in the elderly. OA influences the daily
life of patients and has become a worldwide health problem. It is still unclear whether the …

Gender and sex are key determinants in osteoarthritis not only confounding variables. A systematic review of clinical data

M Tschon, D Contartese, S Pagani, V Borsari… - Journal of clinical …, 2021 - mdpi.com
Many risk factors for osteoarthritis (OA) have been noted, while gender/sex differences have
been understated. The work aimed to systematically review literature investigating as …

Identification of novel targets of knee osteoarthritis shared by cartilage and synovial tissue

C Li, Z Zheng - International Journal of Molecular Sciences, 2020 - mdpi.com
Arthritis is the leading cause of disability among adults, while osteoarthritis (OA) is the most
common form of arthritis that results in cartilage loss. However, accumulating evidence …

Sex specific determinants in osteoarthritis: a systematic review of preclinical studies

D Contartese, M Tschon, M De Mattei… - International journal of …, 2020 - mdpi.com
Osteoarthritis (OA) is a highly prevalent joint disease that primarily affects about 10% of the
world's population over 60 years old. The purpose of this study is to systematically review …