[HTML][HTML] Functional roles of chemokine receptor CCR2 and its ligands in liver disease

S She, L Ren, P Chen, M Wang, D Chen… - Frontiers in …, 2022 - frontiersin.org
Chemokines are a family of cytokines that orchestrate the migration and positioning of
immune cells within tissues and are critical for the function of the immune system. CCR2 …

[HTML][HTML] Emerging importance of chemokine receptor CXCR4 and its ligand in liver disease

S Wang, S Gao, Y Li, X Qian, J Luan… - Frontiers in Cell and …, 2021 - frontiersin.org
Chemokine receptors are members of the G protein-coupled receptor superfamily, which
together with chemokine ligands form chemokine networks to regulate various cellular …

Roles for chemokines in liver disease

F Marra, F Tacke - Gastroenterology, 2014 - Elsevier
Sustained hepatic inflammation is an important factor in progression of chronic liver
diseases, including hepatitis C or non-alcoholic steatohepatitis. Liver inflammation is …

[PDF][PDF] Hepatic macrophage migration and differentiation critical for liver fibrosis is mediated by the chemokine receptor C‐C motif chemokine receptor 8 in mice

F Heymann, L Hammerich, D Storch, M Bartneck… - …, 2012 - Wiley Online Library
Chemokines critically control the infiltration of immune cells upon liver injury, thereby
promoting hepatic inflammation and fibrosis. The chemokine receptor CCR8 can affect …

Serum chemokine receptor CXCR3 ligands are associated with progression, organ dysfunction and complications of chronic liver diseases

F Tacke, HW Zimmermann, ML Berres… - Liver …, 2011 - Wiley Online Library
Background: Chemokines are chemotactic mediators that are implicated in liver diseases. In
viral hepatitis and primary biliary cirrhosis, a predominant chemokine receptor expressed in …

Regulation and functional roles of chemokines in liver diseases

S Cao, M Liu, TS Sehrawat, VH Shah - … Reviews Gastroenterology & …, 2021 - nature.com
Inflammation is a major contributor to the pathogenesis of almost all liver diseases. Low-
molecular-weight proteins called chemokines are the main drivers of liver infiltration by …

CC-chemokine receptor 6 and its ligand macrophage inflammatory protein 3α might be involved in the amplification of local necroinflammatory response in the liver

Y Shimizu, H Murata, Y Kashii, K Hirano, H Kunitani… - Hepatology, 2001 - Elsevier
It is not fully understood how antigen-specific or-nonspecific T cells migrate into the liver in
various liver diseases. Macrophage inflammatory protein (MIP)-3α is a chemokine that is …

Chemokines in liver inflammation and fibrosis

HE Wasmuth, F Tacke, C Trautwein - Seminars in liver disease, 2010 - thieme-connect.com
Chemokines are a class of small chemotactic molecules with cytokine-like functions, which
are well known to orchestrate inflammatory responses within different organs. Overall, more …

[PDF][PDF] C‐C motif chemokine receptor 9 positive macrophages activate hepatic stellate cells and promote liver fibrosis in mice

P Chu, N Nakamoto, H Ebinuma, S Usui, K Saeki… - …, 2013 - Wiley Online Library
Chemokine receptors mediate migration of immune cells into the liver, thereby promoting
liver inflammation. C‐C motif chemokine receptor (CCR) 9+ macrophages are crucial in the …

Functional role of chemokines in liver disease models

H Sahin, C Trautwein, HE Wasmuth - Nature Reviews Gastroenterology …, 2010 - nature.com
Chemokines are a class of small cytokine-like molecules that orchestrate immune cell
infiltration into the liver in response to acute and chronic injuries. Apart from their …