Ischemic stroke is one of the most vital causes of high neurological morbidity and mortality in
the world. Preconditioning exercise is considered as the primary prevention of stroke to …

Introduction Cerebral ischemia reperfusion injury (CIRI) often leads to deleterious
complications after stroke patients receive reperfusion therapy. Exercise preconditioning …

Introduction Mitogen-activated protein kinase (MAPK) pathway is a major mechanism of
acute brain damage in ischemic stroke. Pre-ischemic exercise is an effective method to …

Previous studies have reported that physical exercise may exert a neuroprotective effect in
humans as well as animals. However, the detailed mechanisms underlying the …

Background Exercise preconditioning (EP) is essential for preventing ischemic stroke.
Recent studies have shown that EP exerts neuroprotective effects in the cerebral ischemia …

Background Early exercise after stroke promoted angiogenesis and increased microvessles
density. However, whether these newly formatted vessels indeed give rise to functional …

Objective: Preconditioning exercise can exert neuroprotective effects after stroke; however,
the effects of exercise intensity, frequency, duration are unknown. We investigated the …

Preconditioning exercise prior to stroke exerts neuroprotection, which is an endogenous
strategy that leads the brain cells to express several intrinsic factors and inhibits their …

Objective To explore the influence of exercise preconditioning (EP) on the activity of the toll-
like receptor (TLR) 4/nuclear factor (NF)-κB signaling pathway in a rat model of cerebral …

Ischemic preconditioning (IPC) has been demonstrated to provide a neuroprotection against
brain damage produced by focal cerebral ischemia. However, it is elusive whether ischemic …