Rapid generation of durable B cell memory to SARS-CoV-2 spike and nucleocapsid proteins in COVID-19 and convalescence
GE Hartley, ESJ Edwards, PM Aui, N Varese… - Science …, 2020 - science.org
Lasting immunity following SARS-CoV-2 infection is questioned because serum antibodies
decline in convalescence. However, functional immunity is mediated by long-lived memory T …
decline in convalescence. However, functional immunity is mediated by long-lived memory T …
[HTML][HTML] Memory B cells targeting SARS-CoV-2 spike protein and their dependence on CD4+ T cell help
J Pušnik, E Richter, B Schulte, R Dolscheid-Pommerich… - Cell Reports, 2021 - cell.com
Memory B cells seem to be more durable than antibodies and thus crucial for the long-term
immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection …
immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection …
[HTML][HTML] Switched and unswitched memory B cells detected during SARS-CoV-2 convalescence correlate with limited symptom duration
KL Newell, DC Clemmer, JB Cox, YI Kayode… - PLoS …, 2021 - journals.plos.org
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the causative agent of the
pandemic human respiratory illness COVID-19, is a global health emergency. While severe …
pandemic human respiratory illness COVID-19, is a global health emergency. While severe …
[HTML][HTML] Profiling B cell immunodominance after SARS-CoV-2 infection reveals antibody evolution to non-neutralizing viral targets
Dissecting the evolution of memory B cells (MBCs) against SARS-CoV-2 is critical for
understanding antibody recall upon secondary exposure. Here, we used single-cell …
understanding antibody recall upon secondary exposure. Here, we used single-cell …
[HTML][HTML] Longitudinal analysis shows durable and broad immune memory after SARS-CoV-2 infection with persisting antibody responses and memory B and T cells
Ending the COVID-19 pandemic will require long-lived immunity to SARS-CoV-2. Here, we
evaluate 254 COVID-19 patients longitudinally up to 8 months and find durable broad-based …
evaluate 254 COVID-19 patients longitudinally up to 8 months and find durable broad-based …
Pattern of circulating SARS‐CoV‐2‐specific antibody‐secreting and memory B‐cell generation in patients with acute COVID‐19
M Byazrova, G Yusubalieva… - Clinical & …, 2021 - Wiley Online Library
Objectives To predict the spread of coronavirus disease (COVID‐19), information regarding
the immunological memory for disease‐specific antigens is necessary. The possibility of …
the immunological memory for disease‐specific antigens is necessary. The possibility of …
[HTML][HTML] Durable SARS-CoV-2 B cell immunity after mild or severe disease
Multiple studies have shown loss of severe acute respiratory syndrome coronavirus 2–
specific (SARS-CoV-2–specific) antibodies over time after infection, raising concern that …
specific (SARS-CoV-2–specific) antibodies over time after infection, raising concern that …
[HTML][HTML] SARS-CoV-2–specific memory B cells can persist in the elderly who have lost detectable neutralizing antibodies
A Jeffery-Smith, AR Burton, S Lens… - The Journal of …, 2022 - Am Soc Clin Investig
Memory B cells (MBCs) can provide a recall response able to supplement waning
antibodies (Abs) with an affinity-matured response better able to neutralize variant viruses …
antibodies (Abs) with an affinity-matured response better able to neutralize variant viruses …
S protein-reactive IgG and memory B cell production after human SARS-CoV-2 infection includes broad reactivity to the S2 subunit
P Nguyen-Contant, AK Embong, P Kanagaiah… - MBio, 2020 - Am Soc Microbiol
The high susceptibility of humans to severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) infection, the cause of coronavirus disease 2019 (COVID-19), reflects the …
(SARS-CoV-2) infection, the cause of coronavirus disease 2019 (COVID-19), reflects the …
[HTML][HTML] Maturation and persistence of the anti-SARS-CoV-2 memory B cell response
Memory B cells play a fundamental role in host defenses against viruses, but to date, their
role has been relatively unsettled in the context of SARS-CoV-2. We report here a …
role has been relatively unsettled in the context of SARS-CoV-2. We report here a …
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