Alzheimer's disease (AD) is the most prevalent type of dementia. Down syndrome (DS) is the
leading genetic risk factor for Early-Onset AD, prematurely presenting the classic …

Virtually all adults with Down syndrome (DS) show the neuropathological changes of
Alzheimer disease (AD) by the age of 40 years. This association is partially due to …

Chromosome 21, triplicated in Down Syndrome, contains several genes that are thought to
play a critical role in the development of AD neuropathology. The overexpression of the …

Background Down syndrome (DS), caused by chromosome 21 trisomy, is associated with an
ultra-high risk of dementia due to Alzheimer's disease (AD), driven by amyloid precursor …

Down syndrome (DS) is the leading cause of genetically-defined intellectual disability and
congenital birth defects. Despite being one of the first genetic diseases identified, only …

Abstract Introduction People with Down syndrome (DS) are predisposed to Alzheimer's
disease (AD). The amyloid hypothesis informs studies of AD. In AD‐DS, but not sporadic AD …

Alzheimer's disease (AD) may affect in excess of 90% of individuals with Down syndrome
(DS) after age 60, due to duplication of the APP gene in trisomy of chromosome 21, with …

Individuals with Down syndrome (DS) have an increased risk of early-onset Alzheimer's
Disease (AD), largely owing to a triplication of the APP gene, located on chromosome 21. In …

The mechanisms by which trisomy 21 leads to the characteristic Down syndrome (DS)
phenotype are unclear. We used whole genome microarrays to characterize for the first time …

Background: Down syndrome (DS) is caused by either complete or partial triplication of
chromosome 21, affecting approximately 1/1000 live births, and it is widely accepted that …