Autoimmune kidney diseases occur due to the loss of tolerance to self-antigens, resulting in
inflammation and pathological damage to the kidneys. This review focuses on the known …

Recent genome-wide association studies (GWAS) have identified multiple susceptibility loci
for immunoglobulin A nephropathy (IgAN), the most common form of glomerulonephritis …

Primary glomerulonephritis is a major global health concern and a disorder with significant
heritable components. Rapid advances in sequencing technologies have led to genome …

An autoimmune component has been suggested to play a role in pathogenesis of IgA
nephropathy (IgAN). And genetic studies have reported the shared susceptibility loci …

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by
multiple system involvement and positive serum autoantibodies. Lupus nephritis (LN) is the …

Prior research has established associations between immune cells, inflammatory proteins,
and chronic kidney disease (CKD). Our Mendelian randomization study aims to elucidate …

Results Ninety-six SNPs mapping to 60 SLE loci with reported P values< 1× 10− 5 were
investigated. CFH (P= 8.41× 10− 6), HLA-DRA (P= 4.91× 10− 6), HLA-DRB1 (P= 9.46× 10 …

IgA nephropathy is the most prevalent primary glomerulonephritis worldwide, with identical
immunopathological characteristics caused by multiple etiologies as well as influenced by …

Neutrophil extracellular traps (NETs) are extracellular DNA structures covered with
antimicrobial peptides, danger molecules, and autoantigens that can be released by …

The genetic background of lupus nephritis (LN) has not been completely elucidated. We
performed a case-only study of 2886 SLE patients, including 947 (33%) with LN. Renal …