Pathogenesis of depression: Insights from human and rodent studies

C Ménard, GE Hodes, SJ Russo - Neuroscience, 2016 - Elsevier
Major depressive disorder (MDD) will affect one out of every five people in their lifetime and
is the leading cause of disability worldwide. Nevertheless, mechanisms associated with the …

Linking molecules to mood: new insight into the biology of depression

V Krishnan, EJ Nestler - American Journal of Psychiatry, 2010 - Am Psychiatric Assoc
Major depressive disorder is a heritable psychiatric syndrome that appears to be associated
with subtle cellular and molecular alterations in a complex neural network. The affected …

[HTML][HTML] Molecular pathways of major depressive disorder converge on the synapse

GR Fries, VA Saldana, J Finnstein, T Rein - Molecular psychiatry, 2023 - nature.com
Major depressive disorder (MDD) is a psychiatric disease of still poorly understood
molecular etiology. Extensive studies at different molecular levels point to a high complexity …

Neuronal correlates of depression

D Chaudhury, H Liu, MH Han - Cellular and Molecular Life Sciences, 2015 - Springer
Major depressive disorder (MDD) is a common psychiatric disorder effecting approximately
121 million people worldwide and recent reports from the World Health Organization (WHO) …

The cellular and molecular basis of major depressive disorder: towards a unified model for understanding clinical depression

E Pitsillou, SM Bresnehan, EA Kagarakis… - Molecular biology …, 2020 - Springer
Major depressive disorder (MDD) is considered a serious public health issue that adversely
impacts an individual's quality of life and contributes significantly to the global burden of …

[PDF][PDF] Current understanding of the neurobiology of major depressive disorder

AL Chiriţă, V Gheorman, D Bondari, I Rogoveanu - Rom J Morphol Embryol, 2015 - rjme.ro
Depression is highly prevalent worldwide and associated with significant morbidity and
mortality. Approximately 340 million people worldwide suffer from depression at any given …

[HTML][HTML] Neuroinflammatory basis of depression: learning from experimental models

R Afridi, K Suk - Frontiers in cellular neuroscience, 2021 - frontiersin.org
The neuroinflammatory basis of depression encompasses the detrimental role of otherwise
supportive non-neuronal cells and neuroinflammation in hampering neuronal function …

The effects of psychological stress on depression

L Yang, Y Zhao, Y Wang, L Liu… - Current …, 2015 - ingentaconnect.com
Major depressive disorder is a serious mental disorder that profoundly affects an individual's
quality of life. Although the aetiologies underlying this disorder remain unclear, an …

Depression and treatment response: dynamic interplay of signaling pathways and altered neural processes

V Duric, RS Duman - Cellular and molecular life sciences, 2013 - Springer
Since the 1960s, when the first tricyclic and monoamine oxidase inhibitor antidepressant
drugs were introduced, most of the ensuing agents were designed to target similar brain …

Molecular aspects of depression: a review from neurobiology to treatment

GRV Boas, RB de Lacerda, MM Paes, P Gubert… - European journal of …, 2019 - Elsevier
Major depressive disorder (MDD), also known as unipolar depression, is one of the leading
causes of disability and disease worldwide. The signs and symptoms are low self‑esteem …