[HTML][HTML] Anticancer effects and molecular mechanisms of apigenin in cervical cancer cells

YH Chen, JX Wu, SF Yang, CK Yang, TH Chen… - Cancers, 2022 - mdpi.com
Simple Summary The present study investigated the anticancer effects and molecular
mechanisms of apigenin in cervical cancer in vitro and in vivo. HeLa and C33A cells were …

Apigenin induced apoptosis through p53-dependent pathway in human cervical carcinoma cells

PW Zheng, LC Chiang, CC Lin - Life sciences, 2005 - Elsevier
Apigenin is a widely distributed plant flavonoid and was proposed as an antitumor agent. In
this study, we reported for the first time that apigenin inhibited the growth of human cervical …

[HTML][HTML] Apigenin inhibits proliferation and invasion, and induces apoptosis and cell cycle arrest in human melanoma cells

G Zhao, X Han, W Cheng, J Ni… - Oncology …, 2017 - spandidos-publications.com
Malignant melanoma is the most invasive and fatal form of cutaneous cancer. Moreover it is
extremely resistant to conventional chemotherapy and radiotherapy. Apigenin, a non …

[HTML][HTML] Apigenin in cancer therapy: Anti-cancer effects and mechanisms of action

X Yan, M Qi, P Li, Y Zhan, H Shao - Cell & bioscience, 2017 - Springer
Apigenin is a common dietary flavonoid that is abundantly present in many fruits, vegetables
and Chinese medicinal herbs and serves multiple physiological functions, such as strong …

Apigenin 7-O-glucoside promotes cell apoptosis through the PTEN/PI3K/AKT pathway and inhibits cell migration in cervical cancer HeLa cells

MM Liu, RH Ma, ZJ Ni, K Thakur… - Food and Chemical …, 2020 - Elsevier
Epidemiologic evidence promote the inclusion of flavones in diet due to their inhibitory
effects on certain types of cancers, particularly in women. Among the naturally occurring …

[HTML][HTML] Apigenin inhibits histamine-induced cervical cancer tumor growth by regulating estrogen receptor expression

E Zhang, Y Zhang, Z Fan, L Cheng, S Han, H Che - Molecules, 2020 - mdpi.com
Apigenin is a natural flavone with anti-inflammatory and antioxidant properties and antitumor
abilities against several types of cancers. Previous studies have found that the antitumor …

[HTML][HTML] The potential role of apigenin in cancer prevention and treatment

AH Rahmani, MA Alsahli, A Almatroudi, MA Almogbel… - Molecules, 2022 - mdpi.com
Cancer is the leading cause of death worldwide. In spite of advances in the treatment of
cancer, currently used treatment modules including chemotherapy, hormone therapy …

[HTML][HTML] Apigenin induces apoptosis by regulating Akt and MAPK pathways in human melanoma cell A375SM

JS Woo, GS Choo, ES Yoo… - Molecular …, 2020 - spandidos-publications.com
Apigenin, an aromatic compound, exhibits antioxidant, anti‑inflammatory and anti‑viral
effects. The present study aimed to investigate the effects of apigenin on cell proliferation …

[HTML][HTML] Apigenin role as cell-signaling pathways modulator: implications in cancer prevention and treatment

Z Javed, H Sadia, MJ Iqbal, S Shamas, K Malik… - Cancer Cell …, 2021 - Springer
Cancer is a complex disease orchestrated by various extrinsic and intrinsic pathways. In
recent years, there has been a keen interest towards the development of natural extracts …

Apigenin inhibits VEGF and HIF‐1 expression via PI3K/AKT/p70S6K1 and HDM2/p53 pathways

J Fang, C Xia, Z Cao, JZ Zheng, E Reed… - The FASEB …, 2005 - Wiley Online Library
Apigenin is a nontoxic dietary flavonoid that has been shown to possess anti‐tumor
properties and therefore poses special interest for the development of a novel …