The limited molecular classifications and disease signatures of osteoarthritis (OA) impede
the development of prediagnosis and targeted therapeutics for OA patients. To classify and …

Introduction Osteoarthritis (OA) is a heterogeneous and complex disease. We have used a
network biology approach based on genome-wide analysis of gene expression in OA knee …

Osteoarthritis causes pain and functional disability for over 500 million people worldwide. To
develop disease-stratifying tools and modifying therapies, we need a better understanding …

Objective Osteoarthritis (OA) is the most prevalent joint disease. As disease-modifying
therapies are not available, novel therapeutic targets need to be discovered and prioritized …

Although osteoarthritis (OA) aetiology is complex, genetic, genomic and epigenetic studies
published within the last decade have advanced our understanding of the molecular …

Objectives To determine how gene expression profiles in osteoarthritis joint tissues relate to
patient phenotypes and whether molecular subtypes can be reproducibly captured by a …

Objectives Understanding the molecular mechanisms underlying human cartilage
degeneration and regeneration is helpful for improving therapeutic strategies for treating …

Osteoarthritis (OA) is a common disease characterized by cartilage degeneration and joint
remodeling. The underlying molecular changes underpinning disease progression are …

Objective To identify key determinants of the interactive pathophysiologic processes in
subchondral bone and cartilage in osteoarthritis (OA). Methods We performed RNA …

INTRODUCTION: Although the extracellular matrix (ECM) is the functional element in
articular cartilage and its degradation is central in the pathogenetic process in osteoarthritis …