Shigella rely on a type III secretion system as the primary virulence factor for invasion and
colonization of human hosts. Although there are an estimated 90 million Shigella infections …

Type III secretion systems (T3SS) are highly conserved virulence factors employed by a
large number of pathogenic gram-negative bacteria. Like many T3SS translocators …

Shigella flexneri causes a severe form of bacillary dysentery also known as shigellosis.
Onset of shigellosis requires bacterial invasion of colonic epithelial cells which is initiated by …

Abstract The Shigella flexneri Type III secretion system (T3SS) senses contact with human
intestinal cells and injects effector proteins that promote pathogen entry as the first step in …

Bacterial Type III Secretion Systems (T3SSs) are specialized multicomponent
nanomachines that mediate the transport of proteins either to extracellular locations or …

Bacterial type III secretion systems (T3SS) are used to inject proteins into mammalian cells
to subvert cellular functions. The Shigella T3SS apparatus (T3SA) is comprised of a basal …

The Shigella pathogenicity factor IpgC belongs to the class II of type III secretion system
chaperones, whose members are characterized by a tetratricopeptide repeat (TPR) domain …

Shigella flexneri uses its type III secretion system (T3SS) to promote invasion of human
intestinal epithelial cells as the first step in causing shigellosis, a life-threatening form of …

The type III secretion system (T3SS) is an essential virulence factor for Shigella flexneri,
providing a conduit through which host-altering effectors are injected directly into a host cell …

Type III secretion systems (TTSSs) utilized by enteropathogenic bacteria require the
presence of small, acidic virulence-associated chaperones for effective host cell infection …