Genetically engineered pigs are now available for xenotransplantation in which all three
known carbohydrate xenoantigens, against which humans have natural antibodies, have …

Xenotransplantation, using genetically-modified pigs for clinical organ transplantation, is a
solution to the organ shortage. The biggest barrier to clinical implementation is the …

Porcine cells devoid of three major carbohydrate xenoantigens, αGal, Neu5GC, and SDa
(TKO) exhibit markedly reduced binding of human natural antibodies. Therefore, it is …

Between the 17th and 20th centuries, blood was transfused from various animal species into
patients with a variety of pathological conditions. Skin grafts were carried out in the 19th …

Xenotransplantation has the potential to deliver an unlimited supply of organs for
transplantation. However, this promise has yet to translate into clinical application, despite …

Research in xenotransplantation has increased enormously in the last eight years. As the
shortage of allogeneic organs has intensified, the possibility of using organs from pigs has …

Background: The recent clinical pig-heart transplant carried out at the University of Maryland
in Baltimore is hopefully the first of many xenotransplants that will resolve the problem of the …

Xenotransplantation: how close are we? | Nature Biotechnology Skip to main content Thank
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▪ Abstract The increasing shortage of human cadaveric organs for purposes of
transplantation has become the critical limiting factor in the number of transplants performed …

The critical shortage of human organs for allotransplantation has led to intensive research
on xenotransplantation, with the pig being the species of choice as an organ source …