The final obstacle to successful pre‐clinical xenotransplantation?
T Yamamoto, H Hara, H Iwase, A Jagdale… - …, 2020 - Wiley Online Library
Genetically engineered pigs are now available for xenotransplantation in which all three
known carbohydrate xenoantigens, against which humans have natural antibodies, have …
known carbohydrate xenoantigens, against which humans have natural antibodies, have …
Aspects of histocompatibility testing in xenotransplantation
JM Ladowski, J Houp, V Hauptfeld-Dolejsek… - Transplant …, 2021 - Elsevier
Xenotransplantation, using genetically-modified pigs for clinical organ transplantation, is a
solution to the organ shortage. The biggest barrier to clinical implementation is the …
solution to the organ shortage. The biggest barrier to clinical implementation is the …
Kidney transplantation from triple‐knockout pigs expressing multiple human proteins in cynomolgus macaques
D Ma, T Hirose, G Lassiter, H Sasaki… - American Journal of …, 2022 - Wiley Online Library
Porcine cells devoid of three major carbohydrate xenoantigens, αGal, Neu5GC, and SDa
(TKO) exhibit markedly reduced binding of human natural antibodies. Therefore, it is …
(TKO) exhibit markedly reduced binding of human natural antibodies. Therefore, it is …
A brief history of clinical xenotransplantation
DKC Cooper, B Ekser, JA Tector - International Journal of Surgery, 2015 - journals.lww.com
Between the 17th and 20th centuries, blood was transfused from various animal species into
patients with a variety of pathological conditions. Skin grafts were carried out in the 19th …
patients with a variety of pathological conditions. Skin grafts were carried out in the 19th …
[HTML][HTML] Clinical xenotransplantation: pigs might fly?
A Dorling - American Journal of Transplantation, 2002 - Elsevier
Xenotransplantation has the potential to deliver an unlimited supply of organs for
transplantation. However, this promise has yet to translate into clinical application, despite …
transplantation. However, this promise has yet to translate into clinical application, despite …
Xenotransplantation: problems and prospects
FH Bach - Annual review of medicine, 1998 - annualreviews.org
Research in xenotransplantation has increased enormously in the last eight years. As the
shortage of allogeneic organs has intensified, the possibility of using organs from pigs has …
shortage of allogeneic organs has intensified, the possibility of using organs from pigs has …
The long and winding road to clinical xenotransplantation: a personal journey
DKC Cooper - European Surgical Research, 2022 - karger.com
Background: The recent clinical pig-heart transplant carried out at the University of Maryland
in Baltimore is hopefully the first of many xenotransplants that will resolve the problem of the …
in Baltimore is hopefully the first of many xenotransplants that will resolve the problem of the …
Xenotransplantation: how close are we?
K Aschheim, L DeFrancesco - Nature Biotechnology, 2023 - nature.com
Xenotransplantation: how close are we? | Nature Biotechnology Skip to main content Thank
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Will the pig solve the transplantation backlog?
DKC Cooper, B Gollackner… - Annual review of …, 2002 - annualreviews.org
▪ Abstract The increasing shortage of human cadaveric organs for purposes of
transplantation has become the critical limiting factor in the number of transplants performed …
transplantation has become the critical limiting factor in the number of transplants performed …
Gene-edited pigs for xenotransplantation
W Eyestone, K Adams, S Ball, J Bianchi… - … : pathways and progress …, 2020 - Springer
The critical shortage of human organs for allotransplantation has led to intensive research
on xenotransplantation, with the pig being the species of choice as an organ source …
on xenotransplantation, with the pig being the species of choice as an organ source …