The most recent Guidelines for the Diagnosis and Management of Asthma from the National
Asthma Education and Prevention Program define the disease as follows:“Asthma is a …

There is little doubt that chronic asthma represents a unique inflammatory process in which
the airway has become the target. Observations that were originally made nearly 100 years …

Asthma is best described as a chronic disease that involves inflammation of the pulmonary
airways and bronchial hyperresponsiveness that results in the clinical expression of a lower …

Context.—Asthma has been defined as a chronic inflammatory disorder of the airways that is
associated with recruitment of inflammatory cells and the clinical development of wheezing …

Asthma is a complex chronic inflammatory disease of the airways that involves the activation
of many inflammatory and structural cells, all of which release inflammatory mediators that …

Asthma is the most common treatable chronic disease of the lung affecting all age groups;
yet its treatability-despite improvements in the potency and selectivity of the drugs used and …

Asthma is a chronic disease associated with variable levels of airflow obstruction.
Considerable evidence has been obtained to show that airway inflammation is a major …

The association of asthma with the release of inflammatory mediators, through a mechanism
that involves the immune system, has taken almost 100 years to evolve. While studies on …

Airway inflammation has emerged as an important contributor to mechanisms of asthma.
Furthermore, the presence of airway inflammation is present even in the absence of severe …

It is now widely accepted that asthma in its varied forms is an inflammatory disorder of the
airways in which mediator release from activated mast cells and eosinophils plays a major …