The permanent cellular constituents of the heart include cardiac fibroblasts, myocytes,
endothelial cells, and vascular smooth muscle cells. Previous studies have demonstrated …

Cardiac fibroblasts produce the extracellular matrix (ECM) scaffold within which the various
cellular components of the heart are organized. As well as providing structural support, it is …

Fibroblasts are at the heart of cardiac function and are the principal determinants of cardiac
fibrosis. Nevertheless, cardiac fibroblasts remain poorly characterized in molecular terms …

Cardiac fibroblasts play a critical role in maintenance of normal cardiac function. They are
indispensable for damage control and tissue remodeling on myocardial injury and principal …

Cardiac fibroblasts deposit and maintain extracellular matrix during organogenesis and
under physiological conditions. In the adult heart, activated cardiac fibroblasts also …

Cardiac fibroblasts are the most abundant cell type in the mammalian heart and comprise
approximately two-thirds of the total number of cardiac cell types. During development …

Cardiac fibroblasts are the most prevalent cell type in the heart and play a key role in
regulating normal myocardial function and in the adverse myocardial remodeling that occurs …

Cardiac fibroblasts are the most abundant cell in the mammalian heart. While they have
been historically underappreciated in terms of their functional contributions to cardiac …

Cardiac fibroblasts are the primary cell type responsible for deposition of extracellular matrix
in the heart, providing support to the contracting myocardium and contributing to a myriad of …

Our understanding of the functions of cardiac fibroblasts has moved beyond their roles in
heart structure and extracellular matrix generation and now includes their contributions to …