Plasma biomarkers predict Alzheimer's disease before clinical onset in Chinese cohorts

H Cai, Y Pang, X Fu, Z Ren, L Jia - Nature Communications, 2023 - nature.com
Plasma amyloid-β (Aβ) 42, phosphorylated tau (p-tau) 181, and neurofilament light chain
(NfL) are promising biomarkers of Alzheimer's disease (AD). However, whether these …

Longitudinal blood biomarker trajectories in preclinical Alzheimer's disease

Y Yakoub, NJ Ashton… - Alzheimer's & …, 2023 - Wiley Online Library
INTRODUCTION Plasma biomarkers are altered years prior to Alzheimer's disease (AD)
clinical onset. METHODS We measured longitudinal changes in plasma amyloid‐beta (Aβ) …

Plasma p‐tau181, p‐tau217, and other blood‐based Alzheimer's disease biomarkers in a multi‐ethnic, community study

AM Brickman, JJ Manly, LS Honig… - Alzheimer's & …, 2021 - Wiley Online Library
Abstract Introduction Blood‐based Alzheimer's disease (AD) biomarkers provide
opportunities for community studies and across ethnic groups. We investigated blood …

Plasma Aβ42/Aβ40 and p-tau181 predict long-term clinical progression in a cohort with amnestic mild cognitive impairment

Z Xiao, W Wu, X Ma, X Liang, J Lu, L Zheng… - Clinical …, 2022 - academic.oup.com
Background Previous studies reported the value of blood-based biomarkers in predicting
Alzheimer disease (AD) progression among individuals with different disease stages …

Detecting amyloid positivity in early Alzheimer's disease using combinations of plasma Aβ42/Aβ40 and p‐tau

S Janelidze, S Palmqvist, A Leuzy… - Alzheimer's & …, 2022 - Wiley Online Library
Introduction We studied usefulness of combining blood amyloid beta (Aβ) 42/Aβ40,
phosphorylated tau (p‐tau) 217, and neurofilament light (NfL) to detect abnormal brain Aβ …

Plasma Aβ42/40 ratio, p‐tau181, GFAP, and NfL across the Alzheimer's disease continuum: a cross‐sectional and longitudinal study in the AIBL cohort

P Chatterjee, S Pedrini, JD Doecke… - Alzheimer's & …, 2023 - Wiley Online Library
Introduction Plasma amyloid beta (Aβ) 1‐42/Aβ1‐40 ratio, phosphorylated‐tau181 (p‐
tau181), glial fibrillary acidic protein (GFAP), and neurofilament light (NfL) are putative blood …

Associations of plasma phosphorylated tau181 and neurofilament light chain with brain amyloid burden and cognition in objectively defined subtle cognitive decline …

Y Huang, Y Li, F Xie, Q Guo - CNS Neuroscience & …, 2022 - Wiley Online Library
Aims There is increasing evidence that plasma biomarkers are specific biomarkers for
Alzheimer's disease (AD) pathology, but their potential utility in Obj‐SCD (objectively …

Plasma p-tau181 level predicts neurodegeneration and progression to Alzheimer's dementia: a longitudinal study

YL Wang, J Chen, ZL Du, H Weng, Y Zhang… - Frontiers in …, 2021 - frontiersin.org
Background: Plasma-based biomarkers would be potential biomarkers for early diagnosis of
Alzheimer's disease (AD) because they are more available and cost-effective than …

Plasma biomarkers identify older adults at risk of Alzheimer's disease and related dementias in a real‐world population‐based cohort

PCL Ferreira, Y Zhang, B Snitz… - Alzheimer's & …, 2023 - Wiley Online Library
Introduction Plasma biomarkers—cost effective, non‐invasive indicators of Alzheimer's
disease (AD) and related disorders (ADRD)—have largely been studied in clinical research …

Specific associations between plasma biomarkers and postmortem amyloid plaque and tau tangle loads

G Salvadó, R Ossenkoppele, NJ Ashton… - EMBO molecular …, 2023 - embopress.org
Several promising plasma biomarkers for Alzheimer's disease have been recently
developed, but their neuropathological correlates have not yet been fully determined. To …