In rodents, the amygdala has been proposed to serve as a key center for the nociceptive
perception. Previous studies have shown that extracellular signal-regulated kinase (ERK) …

Background: Ethyl pyruvate (EP) possesses anti-inflammatory activity. However, the
potential anti-nociceptive value of EP for the treatment of the inflammatory nociception is …

Rationale Pain-related anxiety and depression are well known to be comorbid with chronic
pain and adversely affect patient quality of life. Recent studies have shown that anxiety-like …

Previous experience of chronic pain causes enhanced responses to upcoming noxious
events in both humans and animals, but the underlying mechanisms remain unclear. In the …

Background The rostral anterior cingulate cortex (rACC) has been implicated in the negative
affective response to injury, and importantly, it has been shown that activation of …

Opioid-induced hyperalgesia (OIH) is one of the major problems associated with use of
opioids in perioperative and chronic pain management. The mechanism underlying this …

In addition to treating depression, antidepressant drugs are also a first-line treatment for
neuropathic pain, which is pain secondary to lesion or pathology of the nervous system …

This study aimed to elucidate the opioid mechanisms underlying dexamethasone-induced
pain antihypersensitive effects in neuropathic rats. Dexamethasone (subcutaneous and …

Background Pain affects both sensory and emotional aversive responses, often provoking
anxiety-related diseases when chronic. However, the neural mechanisms underlying the …

Exposure to chronic stress can produce maladaptive neurobiological changes in pathways
associated with pain processing, which may cause stress–induced hyperalgesia (SIH) …