Nanoparticle mediated brain targeted delivery of gallic acid: in vivo behavioral and biochemical studies for improved antioxidant and antidepressant-like activity
Context: Gallic acid had been reported to possess antidepressant like activity, which may be
attributed to its CNS effects like increase in reduced glutathione levels, increased catalase …
attributed to its CNS effects like increase in reduced glutathione levels, increased catalase …
Optimization of brain targeted gallic acid nanoparticles for improved antianxiety-like activity
Ligand coated nanoparticles may improve brain uptake of drugs. To formulate brain targeted
nanoparticles of gallic acid (GA) for improving its antianxiety-like activity. The nanoparticles …
nanoparticles of gallic acid (GA) for improving its antianxiety-like activity. The nanoparticles …
Nanoparticle mediated brain targeted delivery of gallic acid: in vivo behavioral and biochemical studies for protection against scopolamine-induced amnesia
Context: Gallic acid (GA) has well-documented antioxidant and CNS effects affecting
glutathione, catalase and malonaldehyde levels in brain. Objective: This study was …
glutathione, catalase and malonaldehyde levels in brain. Objective: This study was …
Ascorbic acid tethered polymeric nanoparticles enable efficient brain delivery of galantamine: An in vitro-in vivo study
The aim of this work was to enhance the transportation of the galantamine to the brain via
ascorbic acid grafted PLGA-b-PEG nanoparticles (NPs) using SVCT2 transporters of choroid …
ascorbic acid grafted PLGA-b-PEG nanoparticles (NPs) using SVCT2 transporters of choroid …
Galantamine-loaded solid–lipid nanoparticles for enhanced brain delivery: preparation, characterization, in vitro and in vivo evaluations
Galantamine hydrobromide, a promising acetylcholinesterase inhibitor is reported to be
associated with cholinergic side effects. Its poor brain penetration results in lower …
associated with cholinergic side effects. Its poor brain penetration results in lower …
Preparation, characterization and therapeutic properties of gum arabic-stabilized gallic acid nanoparticles
Gallic acid (GA) is a natural phenolic compound with therapeutic effects that are often
challenged by its rapid metabolism and clearance. Therefore, GA was encapsulated using …
challenged by its rapid metabolism and clearance. Therefore, GA was encapsulated using …
Phytol loaded PLGA nanoparticles ameliorate scopolamine-induced cognitive dysfunction by attenuating cholinesterase activity, oxidative stress and apoptosis in …
S Sathya, BG Manogari, K Thamaraiselvi… - Nutritional …, 2022 - Taylor & Francis
Objective: Alzheimer's disease (AD) is an acquired neurological disorder of cognitive and
behavioral impairments, with a long and progressive route. Currently, efforts are being made …
behavioral impairments, with a long and progressive route. Currently, efforts are being made …
Novel luteolin-loaded chitosan decorated nanoparticles for brain-targeting delivery in a sporadic Alzheimer's disease mouse model: focus on antioxidant, anti …
H Abbas, NSE Sayed, NAHA Youssef, P ME Gaafar… - Pharmaceutics, 2022 - mdpi.com
Preparation and evaluation of a non-invasive intranasal luteolin delivery for the
management of cognitive dysfunction in Alzheimer's disease (AD) using novel chitosan …
management of cognitive dysfunction in Alzheimer's disease (AD) using novel chitosan …
Development of glutathione-conjugated asiatic acid-loaded bovine serum albumin nanoparticles for brain-targeted drug delivery
N Raval, T Mistry, N Acharya… - Journal of Pharmacy and …, 2015 - academic.oup.com
Objective Asiatic acid, a well-known plant-based neuroprotective pentacyclic triterpenoid,
has major limitation for its bioavailability in the brain. The objective of this study is to develop …
has major limitation for its bioavailability in the brain. The objective of this study is to develop …
Cerebral effect of optimized Allium sativum oil-loaded chitosan nanorods: GC-MS analysis and in vitro/in vivo evaluation
R Kamel, A Salama, NM Shaffie, NM Salah - Food & function, 2020 - pubs.rsc.org
The chemical constituents of Allium sativum (garlic) oil were investigated using the GC/MS
technique after silylation, and the presence of several fatty acids and their esters was …
technique after silylation, and the presence of several fatty acids and their esters was …