Heart failure with preserved ejection fraction (HFpEF) is an increasingly studied entity
accounting for 50% of all diagnosed heart failure and that has claimed its own dignity being …

Heart failure with preserved ejection fraction (HFpEF) has been recognized as the greatest
single unmet need in cardiovascular medicine. Indeed, the morbi-mortality of HFpEF is high …

A new paradigm has emerged in our understanding of the pathophysiology of heart failure
(HF) with preserved ejection fraction (HFpEF) versus HF with reduced ejection fraction …

Over the past decade, myocardial structure, cardiomyocyte function, and intramyocardial
signaling were shown to be specifically altered in heart failure with preserved ejection …

Coronary microvascular disease (CMD), characterized by impaired coronary flow reserve
(CFR), is a common finding in patients with stable angina. Impaired CFR, in the absence of …

Recently, a new paradigm for the development of heart failure with preserved ejection
fraction (HFpEF) has been proposed, which identifies a systemic pro-inflammatory state …

Renal dysfunction in heart failure with preserved ejection fraction (HFpEF) is common and is
associated with increased mortality. Impaired renal function is also a risk factor for …

Heart failure with preserved ejection fraction (HFpEF) is one of the greatest unmet needs in
modern medicine. The lack of an appropriate therapy may reflect the lack of an accurate …

Aims To date, clinical evidence of microvascular dysfunction in patients with heart failure
(HF) with preserved ejection fraction (HFpEF) has been limited. We aimed to investigate the …

Heart failure with preserved ejection fraction (HFpEF) represents a complex and
heterogeneous clinical syndrome, which is increasingly prevalent and associated with poor …