Concerns exist regarding the potential increased cardiovascular risk from lowering diastolic
blood pressure (DBP) in hypertensive patients. We analyzed 30-year follow-up data of 10 …

Background. A paradoxical increase in cardiovascular events has been reported with
intensively lowering diastolic blood pressure (DBP). This J‐curve phenomenon has …

Previous studies have debated the notion that low blood pressure (BP) during treatment,
particularly diastolic (DBP), is associated with increased risk of cardiovascular disease. We …

We prospectively tested in the combined original and offspring Framingham cohorts the
hypothesis that the increase in cardiovascular disease (CVD) incidence at low diastolic …

Background: Population-based longitudinal studies of hypertension have usually shown a
continuous and positive relationship between blood pressure and mortality. However …

Hypertension remains a leading cause of morbidity and mortality. Recent treatment
guidelines stress more strict systolic blood pressure (SBP) targets without regard for …

Aims It is unclear whether a J-curve association exists in cardiovascular risk prediction and
how independently systolic and diastolic blood pressure (BP) predict cardiovascular …

Recent studies have challenged the notion that “lower is better” for blood pressure in
relation to vascular events and mortality in patients with vascular disease, whereas practice …

The blood pressure J-curve discussion has been ongoing for more than 30 years, yet there
are still questions in need of definitive answers. On one hand, existing antihypertensive …

Background: Low systolic blood pressure (SBP) values are associated with an increased
risk of cardiovascular events, giving rise to the so-called J-curve phenomenon. We assessed …