Effects of catalpol on Alzheimer's disease and its mechanisms

H Chen, C Deng, Z Meng… - … Based Complementary and …, 2022 - Wiley Online Library
Alzheimer's disease (AD) is a degenerative disease of the central nervous system
characterized by memory loss and cognitive dysfunction. With the increasing aging of the …

Further pharmacological evidence of the neuroprotective effect of catalpol from Rehmannia glutinosa

X Zhang, A Zhang, B Jiang, Y Bao, J Wang, L An - Phytomedicine, 2008 - Elsevier
We have previously evaluated the neuroprotective effect of catalpol on aging mice induced
by d-galactose, in which catalpol treatment ameliorated cognition deficits and attenuated …

Therapeutic potential of catalpol and geniposide in Alzheimer's and Parkinson's diseases: a snapshot of their underlying mechanisms

X Zhang, K Liu, M Shi, L Xie, M Deng, H Chen… - Brain Research Bulletin, 2021 - Elsevier
Rehmannia glutinosa, the fresh or dried root of Rehmannia glutinosa (Gaertn.) Libosch. ex
Fisch. & Mey., and Gardenia, the fruit of Gardenia jasminoides Ellis from Rubiaceae, both …

Catalpol: a potential therapeutic for neurodegenerative diseases

B Jiang, RF Shen, J Bi, XS Tian… - Current Medicinal …, 2015 - ingentaconnect.com
Neurodegenerative disorders, eg, Alzheimer's disease (AD) and Parkinson's disease (PD)
are characterized by the progressive loss of neurons and subsequent cognitive decline …

Anti‐inflammatory effect and mechanism of catalpol in various inflammatory diseases

J Liu, S Liu, M Yu, J Li, Z Xie, B Gao… - Drug Development …, 2023 - Wiley Online Library
Catalpol is a kind of iridoid glucoside, widely found in a variety of plants, mostly extracted
from the rhizome of the traditional medicinal herb rehmanniae. It has various biological …

Multiple biological effects of an iridoid glucoside, catalpol, and its underlying molecular mechanisms

SK Bhattamisra, KH Yap, V Rao, H Choudhury - Biomolecules, 2019 - mdpi.com
Catalpol, an iridoid glucoside, is widely distributed in many plant families and is primarily
obtained from the root of Rehmannia glutinosa Libosch. Rehmannia glutinosa is a plant very …

Catalpol preserves neural function and attenuates the pathology of Alzheimer's disease in mice

JZ Huang, J Wu, S Xiang, S Sheng… - Molecular …, 2016 - spandidos-publications.com
Alzheimer's disease (AD) is the most common form of dementia and there currently are no
effective treatment strategies available. Catalpol is an iridoid glucoside, and large quantities …

Effect of catalpol on remyelination through experimental autoimmune encephalomyelitis acting to promote Olig1 and Olig2 expressions in mice

T Yang, Q Zheng, S Wang, L Fang, L Liu… - … and Alternative Medicine, 2017 - Springer
Background Multiple sclerosis (MS) as an autoimmune disorder is a common disease
occurring in central nervous system (CNS) and the remyelination plays a pivotal role in the …

Neuroprotective Mechanisms of Salidroside in Alzheimer's Disease: A Systematic Review and Meta-analysis of Preclinical Studies

N Zhang, J Nao, X Dong - Journal of Agricultural and Food …, 2023 - ACS Publications
Alzheimer's disease (AD) is a neurodegenerative disease of the central nervous system that
occurs in old age and pre-aging, characterized by progressive cognitive dysfunction and …

[HTML][HTML] Catalpol rescues cognitive deficits by attenuating amyloid β plaques and neuroinflammation

S Li, Z Tian, X Xian, C Yan, Q Li, N Li, X Xu… - Biomedicine & …, 2023 - Elsevier
This study sought to investigate the anti-amyloid β (Aβ) and anti-neuroinflammatory effects of
catalpol in an Alzheimer's disease (AD) mouse model. Methods The effects of catalpol on Aβ …