The interplay between Ca 2+ and reactive oxygen species (ROS) signaling pathways is well
established, with reciprocal regulation occurring at a number of subcellular locations. Many …

Calcium is an important second messenger involved in intra-and extracellular signaling
cascades and plays an essential role in cell life and death decisions. The Ca 2+ signaling …

Abstract Calcium ions (Ca 2+) and the complex regulatory system governed by Ca 2+
signaling have been described to be of crucial importance in numerous aspects related to …

Calcium (Ca2+) uptake into the mitochondria shapes cellular Ca2+ signals and acts as a
key effector for ATP generation. In addition, mitochondria-derived reactive oxygen species …

Calcium (Ca2+) is a major second messenger in cells and is essential for the fate and
survival of all higher organisms. Different Ca2+ channels, pumps, or exchangers regulate …

Cancer is caused by defects in the mechanisms underlying cell proliferation and cell death.
Calcium ions are central to both phenomena, serving as major signalling agents with spatial …

Cytosolic Ca 2+ concentration levels fluctuate in an ordered manner along the cell cycle, in
line with the fact that Ca 2+ is involved in the regulation of cell proliferation. Cell proliferation …

Increases in cytosolic free Ca2+ ([Ca2+] i) represent a ubiquitous signalling mechanism that
controls a variety of cellular processes, including proliferation, metabolism and gene …

Calcium ion (Ca2+) signaling is critical to many physiological processes, and its kinetics and
subcellular localization are tightly regulated in all cell types. All Ca2+ flux perturbations …

Abstract Calcium (Ca2+) and reactive oxygen species (ROS) constitute the most important
intracellular signaling molecules participating in the regulation and integration of diverse …