Increasing evidence indicates that metabolic disorders in offspring can result from the
father's diet, but the mechanism remains unclear. In a paternal mouse model given a high-fat …

The discovery of RNAs (for example, messenger RNAs, non-coding RNAs) in sperm has
opened the possibility that sperm may function by delivering additional paternal information …

Several recent studies link parental environments to phenotypes in subsequent generations.
In this work, we investigate the mechanism by which paternal diet affects offspring …

There is a growing body of evidence linking maternal overnutrition to obesity and
psychopathology that can be conserved across multiple generations. Recently, we …

The global rise in obesity and steady decline in sperm quality are two alarming trends that
have emerged during recent decades. In parallel, evidence from model organisms shows …

The paternal heredity of obesity and diabetes induced by a high-fat and/or high-sugar diet
(Western-like diet) has been demonstrated through epidemiological analysis of human …

The prevalence of obesity is increasing worldwide and has tripled in men of reproductive
age since the 1970s. Concerningly, obesity is not only comorbid with other chronic diseases …

Objectives Chronic and high consumption of fat constitutes an environmental stress that
leads to metabolic diseases. We hypothesized that high-fat diet (HFD) transgenerationally …

Introduction The rapid global rise in metabolic disease suggests that nongenetic
environmental factors contribute to disease risk. Early life represents a window of phenotypic …

Poor paternal diet has emerged as a risk factor for metabolic disease in offspring, and
alterations in sperm may be a major mechanism mediating these detrimental effects of diet …