Vagal control of the heart: central serotonergic (5‐HT) mechanisms

D Jordan - Experimental physiology, 2005 - Wiley Online Library
Cardiac vagal preganglionic neurones (CVPNs) are located within the dorsal vagal nucleus
(DVN) and the nucleus ambiguus (nA). In mammals, CVPNs within the nA have small …

The role of central 5‐HT3 receptors in vagal reflex inputs to neurones in the nucleus tractus solitarius of anaesthetized rats

RD Jeggo, DO Kellett, Y Wang… - The Journal of …, 2005 - Wiley Online Library
Brainstem 5‐hydroxytryptamine (5‐HT, serotonin)‐containing neurones modulate
cardiovascular reflex responses but the differing roles of the many 5‐HT receptors have not …

A highly selective cardiorenal serotonergic 5-HT3-mediated reflex in rats

R Veelken, KF Hilgers, M Leonard… - American Journal …, 1993 - journals.physiology.org
To elucidate whether prolonged stimulation of cardiopulmonary serotonergic (5-HT3)
receptors could play a role in the control of renal sympathetic nerve activity (RSNA), we …

Cardiovascular effects from stimulation of 5‐hydroxytryptamine receptors

PR Saxena - Fundamental & clinical pharmacology, 1989 - Wiley Online Library
The cardiovascular effects of 5‐hydroxytryptamine (5‐HT), consisting of bradycardia or
tachycardia, hypotension or hypertension, and vasodilatation or vasoconstriction, are …

Influence of 5-HT1A receptor agonists on sympathetic and parasympathetic nerve activity

AG Ramage - Journal of cardiovascular pharmacology, 1990 - journals.lww.com
Activity in central sympathetic pathways can be modified by stimulating central ai-
adrenoceptors. eg. with clonidine, or, more recently, by stimulating central 5 …

Central 5‐HT7 receptors are critical for reflex activation of cardiac vagal drive in anaesthetized rats

DO Kellett, AG Ramage, D Jordan - The Journal of physiology, 2005 - Wiley Online Library
5‐Hydroxytryptamine (5‐HT; serotonin)‐containing neurones contribute to reflex activation
of parasympathetic outflow in a number of species, but the 5‐HT receptors mediating these …

Stimulation of 5-HT3 receptors in the NTS inhibits the cardiac Bezold-Jarisch reflex response

C Sévoz, A Nosjean, JC Callera… - American Journal …, 1996 - journals.physiology.org
Intra-atrial administration of phenylbiguanide has been shown to trigger, through the
stimulation of vagal afferent C-fibers, reflex bradycardia, hypotension, and …

Evidence that 5-HT3 receptors in the nucleus tractus solitarius and other brainstem areas modulate the vagal bradycardia evoked by activation of the von Bezold …

JGP Pires, SR Silva, AG Ramage, HA Futuro-Neto - Brain research, 1998 - Elsevier
The effects of intracisternal (ic) application of the 5-HT3 receptor antagonist granisetron
(0.016–0.16 μg kg− 1) and the agonist phenylbiguanide (0.3–3 μg kg− 1) on reflex …

Central cardiovascular regulation and 5-hydroxytryptamine receptors

AG Ramage - Brain research bulletin, 2001 - Elsevier
Evidence is provided to support the view that central 5-HT1A and 5-HT2 receptors are the
major receptor subtypes important in cardiovascular regulation. Data are also provided to …

Cardiovascular effects of serotonin agonists and antagonists

PR Saxena, CM Villaló - Journal of cardiovascular pharmacology, 1990 - journals.lww.com
The effects of serotonin (5-hydroxytrypta-mine; 5-HT) on the cardiovascular system are
complex. These effects, consisting of bradycardia or tachycardia, hypotension or …