A hybrid fluorescent nanofiber membrane integrated with microfluidic chips towards lung-on-a-chip applications

P Kanabekova, B Dauletkanov, Z Bekezhankyzy… - Lab on a Chip, 2024 - pubs.rsc.org
Here, we report a fluorescent electrospun nanofiber membrane for integration into
microfluidic devices towards lung-on-a-chip applications complemented with the results of …

An Integrated and Modular Compartmentalized Microfluidic System with Tunable Electrospun Porous Membranes for Epithelialized Organs-on-a-Chip

RS Fardous, S Alshmmari, E Tawfik… - … Applied Materials & …, 2024 - ACS Publications
A modular and 3D compartmentalized microfluidic system with electrospun porous
membranes (PMs) for epithelialized organ-on-a-chip systems is presented. Our novel …

Nanofiber membrane supported lung-on-a-chip microdevice for anti-cancer drug testing

X Yang, K Li, X Zhang, C Liu, B Guo, W Wen, X Gao - Lab on a Chip, 2018 - pubs.rsc.org
Organ-on-a-chip technology can simulate the physiological and pathological
microenvironment of tissues and organs in vitro, thus offering the potential of dispensing with …

PLGA nanofiber/PDMS microporous composite membrane-sandwiched microchip for drug testing

W Li, X Sun, B Ji, X Yang, B Zhou, Z Lu, X Gao - Micromachines, 2020 - mdpi.com
Lung-on-a-chip devices could provide new strategies for a biomimetic lung cell
microenvironment and construction of lung disease models in vitro, and are expected to …

Peptide-functionalized electrospun meshes for the physiological cultivation of pulmonary alveolar capillary barrier models in a 3D-printed micro-bioreactor

P Jain, SB Rauer, D Felder, J Linkhorst… - ACS Biomaterials …, 2023 - ACS Publications
In vitro environments that realize biomimetic scaffolds, cellular composition, physiological
shear, and strain are integral to developing tissue models of organ-specific functions. In this …

A high-performance polydimethylsiloxane electrospun membrane for cell culture in lab-on-a-chip

H Moghadas, MS Saidi, N Kashaninejad… - Biomicrofluidics, 2018 - pubs.aip.org
Thin porous membranes are important components in a microfluidic device, serving as
separators, filters, and scaffolds for cell culture. However, the fabrication and the integration …

Evaluation of membranes for mimicry of an alveolar-capillary barrier in microfluidic lung-on-a-chip devices

A Kadyrova, P Kanabekova, A Martin… - Materials Today …, 2022 - Elsevier
An alveolar basement membrane plays a crucial role in the organogenesis and functioning
of the lungs at the alveoli level. To emulate the function of the basement membrane in …

Use of electrospinning and dynamic air focusing to create three-dimensional cell culture scaffolds in microfluidic devices

C Chen, BT Mehl, SA Sell, RS Martin - Analyst, 2016 - pubs.rsc.org
Organs-on-a-chip has emerged as a powerful tool for pharmacological and physiological
studies. A key part in the construction of such a model is the ability to pattern or culture cells …

A microfluidic lung‐on‐a‐chip based on biomimetic hydrogel membrane

C Shen, H Yang, W She, Q Meng - Biotechnology and …, 2023 - Wiley Online Library
Lung‐on‐chips have showed great promise as a tool to recapitulate the respiratory system
for investigation of lung diseases in the past decade. However, the commonly applied …

Integrated electrochemical measurement of endothelial permeability in a 3D hydrogel-based microfluidic vascular model

JF Wong, MD Mohan, EWK Young… - Biosensors and …, 2020 - Elsevier
Mimicking the physiological or pathophysiological barrier function of endothelial and
epithelial cells is an essential consideration in organ-on-a-chip models of numerous tissues …