The success of gene therapy relies on gene nanocarriers to achieve therapeutic effects in
vivo. Surface shielding of poly (ethylene glycol)(PEG), known as PEGylation, onto gene …

Gene therapy holds great promise for the treatment of acquired and inherited diseases. Non-
viral gene delivery systems are gaining recognition as alternatives to viral gene vectors due …

Treatment of diseases on the molecular level by genetic material is limited by effective
delivery mechanisms. We focused on the synthesis of a pH-sensitive gene delivery vehicle …

In recent years, various carriers for gene delivery have been developed for biomedical
applications. Among all kinds of gene carriers, cationic polymeric carriers for delivery …

Nanoparticle-mediated gene delivery is a promising alternative to viral methods; however,
its use in vivo, particularly following systemic injection, has suffered from poor delivery …

The success of anti-cancer therapies largely depends on the ability of the therapeutics to
reach their designated cellular and intracellular target sites, while minimizing accumulation …

There is growing interest in PEGylation of cationic polymeric vehicles for gene delivery in
order to improve vehicle stability and reduce toxicity, but little is known about the effects of …

In this study, a pH-responsive detachable polyethylene glycol (PEG) shielding strategy was
designed for gene delivery in cancer therapy. Polyethylenimine/DNA complex (PEI/DNA) …

Polymeric nano-carriers have been developed as a most capable and feasible technology
platform for gene therapy. As vehicles, polymeric nano-carriers are obliged to possess high …

A tumor-targeted surface charge switchable polymeric gene delivery system with the
function of switching surface charge upon reaching the tumor site owing to the tumor …