PD-L1 negatively regulates CD4+CD25+Foxp3+ Tregs by limiting STAT-5 phosphorylation in patients chronically infected with HCV
D Franceschini, M Paroli, V Francavilla… - The Journal of …, 2009 - Am Soc Clin Investig
CD4+ CD25+ Foxp3+ Tregs suppress autoimmune responses. In addition, they limit T cell
responses during chronic infection, thereby minimizing T cell–dependent immunopathology …
responses during chronic infection, thereby minimizing T cell–dependent immunopathology …
Functional study of CD4+ CD25+ regulatory T cells in health and autoimmune hepatitis
Abstract Regulatory CD4+ CD25+ T cells (Tregs) are defective numerically and functionally
in autoimmune hepatitis (AIH). We have investigated and compared the mechanism of …
in autoimmune hepatitis (AIH). We have investigated and compared the mechanism of …
Low-dose interleukin-2 promotes STAT-5 phosphorylation, Treg survival and CTLA-4-dependent function in autoimmune liver diseases
HC Jeffery, LE Jeffery, P Lutz, M Corrigan… - Clinical & …, 2017 - academic.oup.com
Summary CD4+ CD25highCD127lowforkhead box protein 3 (FoxP3+) regulatory T cells
(Treg) are essential for the maintenance of peripheral tolerance. Impaired Treg function and …
(Treg) are essential for the maintenance of peripheral tolerance. Impaired Treg function and …
Regulatory T cells in hepatitis B and C virus infections
Hepatitis B virus (HBV) and hepatitis C virus (HCV) are hepatotropic viruses that establish
chronic persistent infection by effectively escaping the host immune response and can …
chronic persistent infection by effectively escaping the host immune response and can …
Dynamic programmed death 1 expression by virus-specific CD8 T cells correlates with the outcome of acute hepatitis B
Background & Aims: Recent studies have shown that programmed death 1 (PD-1)
expression can impair virus-specific CD8 T-cell responses during chronic viral infection …
expression can impair virus-specific CD8 T-cell responses during chronic viral infection …
Combined blockade of programmed death-1 and activation of CD137 increase responses of human liver T cells against HBV, but not HCV
P Fisicaro, C Valdatta, M Massari, E Loggi, L Ravanetti… - Gastroenterology, 2012 - Elsevier
BACKGROUND & AIMS: In patients with chronic hepatitis B virus (HBV) and hepatitis C virus
(HCV) infections, antiviral functions of T cells are impaired; these might be increased by …
(HCV) infections, antiviral functions of T cells are impaired; these might be increased by …
T-cell regulation by CD4 regulatory T cells during hepatitis B and C virus infections: facts and controversies
T Manigold, V Racanelli - The Lancet infectious diseases, 2007 - thelancet.com
In the past few years, we have witnessed extraordinary advances in the understanding of the
functions of regulatory T (Treg) cells in immunity against pathogens. However, controversy …
functions of regulatory T (Treg) cells in immunity against pathogens. However, controversy …
[PDF][PDF] Foxp3+ regulatory T cells protect the liver from immune damage and compromise virus control during acute experimental hepatitis B virus infection in mice
L Stross, J Günther, G Gasteiger, T Asen, S Graf… - …, 2012 - Wiley Online Library
The strength of antiviral T cell responses correlates with clearance of hepatitis B virus (HBV)
infection, but the immunological mechanisms mitigating or suppressing HBV‐specific T cells …
infection, but the immunological mechanisms mitigating or suppressing HBV‐specific T cells …
Intrahepatic levels of PD-1/PD-L correlate with liver inflammation in chronic hepatitis B
J Chen, XM Wang, XJ Wu, Y Wang, H Zhao… - Inflammation …, 2011 - Springer
Background and objective Programed cell death-1 (PD-1) represents a mechanism of T-cell
dysfunction in hepatitis B virus (HBV) persistence. In peripheral blood, PD-1 is up-regulated …
dysfunction in hepatitis B virus (HBV) persistence. In peripheral blood, PD-1 is up-regulated …
PD-1 upregulation is associated with HBV-specific T cell dysfunction in chronic hepatitis B patients
G Peng, S Li, W Wu, X Tan, Y Chen, Z Chen - Molecular immunology, 2008 - Elsevier
Programmed death-1 (PD-1) is demonstrated to have an increased expression on antigen-
specific T cells during chronic virus infections, and the blockage of PD-1/PD-ligand (PD-L1) …
specific T cells during chronic virus infections, and the blockage of PD-1/PD-ligand (PD-L1) …