Metals in Alzheimer's disease

M Babić Leko, L Langer Horvat, E Španić Popovački… - Biomedicines, 2023 - mdpi.com
The role of metals in the pathogenesis of Alzheimer's disease (AD) is still debated. Although
previous research has linked changes in essential metal homeostasis and exposure to …

Plasma metals as potential biomarkers in dementia: a case–control study in patients with sporadic Alzheimer's disease

J Xu, SJ Church, S Patassini, P Begley, KAB Kellett… - Biometals, 2018 - Springer
Sporadic Alzheimer's disease (AD) is a neurodegenerative disorder that causes the most
prevalent form of age-related dementia but its pathogenesis remains obscure. Altered …

Serum copper, zinc, and iron levels in patients with Alzheimer's disease: a meta-analysis of case-control studies

DD Li, W Zhang, ZY Wang, P Zhao - Frontiers in aging neuroscience, 2017 - frontiersin.org
Background: Many publications have investigated the association between metal ions and
the risk of Alzheimer's disease (AD), but the results were ambiguous. Aims: The objective of …

The role of metals in the etiology of Alzheimer's disease

I Shcherbatykh, DO Carpenter - Journal of Alzheimer's …, 2007 - content.iospress.com
Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most
common cause of dementia, affecting millions of men and women worldwide. It is …

Trace elements and Alzheimer dementia in population-based studies: A bibliometric and meta-analysis

K Li, A Li, Y Mei, J Zhao, Q Zhou, Y Li, M Yang… - Environmental Pollution, 2023 - Elsevier
Alterations in the concentrations of trace elements may play a vital role in Alzheimer
dementia progression. However, previous research results are inconsistent, and there is still …

[PDF][PDF] Metal ions in Alzheimer's disease brain

M Sastre, CW Ritchie, N Hajji - JSM Alzheimer's Dis. Relat …, 2015 - researchgate.net
There is substantial evidence supporting a critical role for metal ions in the pathogenesis of
Alzheimer's disease (AD). This originated with the observation that certain metal ions …

Homeostasis of metals in the progression of Alzheimer's disease

R Gonzalez-Dominguez, T Garcia-Barrera… - Biometals, 2014 - Springer
In order to study the involvement of metals in the progression of Alzheimer's disease, serum
samples from patients with Alzheimer and mild cognitive impairment were investigated. For …

Evidence for widespread, severe brain copper deficiency in Alzheimer's dementia

J Xu, SJ Church, S Patassini, P Begley… - Metallomics, 2017 - academic.oup.com
Datasets comprising simultaneous measurements of many essential metals in Alzheimer's
disease (AD) brain are sparse, and available studies are not entirely in agreement. To …

Heavy metals and essential metals are associated with cerebrospinal fluid biomarkers of Alzheimer's disease

M Babić Leko, M Mihelčić, J Jurasović… - International journal of …, 2022 - mdpi.com
Various metals have been associated with the pathogenesis of Alzheimer's disease (AD),
principally heavy metals that are environmental pollutants (such as As, Cd, Hg, and Pb) and …

Metallostasis in Alzheimer's disease

S Ayton, P Lei, AI Bush - Free Radical Biology and Medicine, 2013 - Elsevier
Abstract 2012 has been another year in which multiple large-scale clinical trials for
Alzheimer's disease (AD) have failed to meet their clinical endpoints. With the social and …