Targeting of antigens to B cells augments antigen-specific T-cell responses and breaks immune tolerance to tumor-associated antigen MUC1
C Ding, L Wang, J Marroquin… - Blood, The Journal of the …, 2008 - ashpublications.org
B cells are antibody (Ab)–secreting cells as well as potent antigen (Ag)–presenting cells that
prime T-cell activation, which evokes great interest in their use for vaccine development …
prime T-cell activation, which evokes great interest in their use for vaccine development …
Effective immunotherapy of cancer in MUC1-transgenic mice using clonal cytotoxic T lymphocytes directed against an immunodominant MUC1 epitope
LC Heukamp, T van Hall, F Ossendorp… - Journal of …, 2002 - journals.lww.com
The tumor-associated autoantigen MUC1 is intensively studied as a potential target for
antigen-specific immunotherapy of cancer. Previous reports concerning experiments in …
antigen-specific immunotherapy of cancer. Previous reports concerning experiments in …
CD4+ lymphocytes provide MUC1-specific tumor immunity in vivo that is undetectable in vitro and is absent in MUC1 transgenic mice
RM Tempero, ML VanLith, K Morikane… - The Journal of …, 1998 - journals.aai.org
Abstract A C57BL/6 mouse transgenic for human MUC1 (MUC1. Tg) was developed to
evaluate MUC1-specific tumor immunity in an animal that expresses MUC1 as a normal self …
evaluate MUC1-specific tumor immunity in an animal that expresses MUC1 as a normal self …
Selection and characterization of MUC1‐specific CD8+ T cells from MUC1 transgenic mice immunized with dendritic‐carcinoma fusion cells
J Gong, V Apostolopoulos, D Chen, H Chen… - …, 2000 - Wiley Online Library
Mice transgenic for the human MUC1 carcinoma‐associated antigen (MUC1. Tg) are
tolerant to immunization with MUC1 antigen. Recent studies, however, have demonstrated …
tolerant to immunization with MUC1 antigen. Recent studies, however, have demonstrated …
Lack of effective MUC1 tumor antigen-specific immunity in MUC1-transgenic mice results from a Th/T regulatory cell imbalance that can be corrected by adoptive …
MS Turner, PA Cohen, OJ Finn - The Journal of Immunology, 2007 - journals.aai.org
Glycoprotein tumor Ag MUC1 is overexpressed on the majority of epithelial
adenocarcinomas. CTLs that recognize MUC1 and can kill tumor cells that express this …
adenocarcinomas. CTLs that recognize MUC1 and can kill tumor cells that express this …
Three different vaccines based on the 140-amino acid MUC1 peptide with seven tandemly repeated tumor-specific epitopes elicit distinct immune effector mechanisms …
MM Soares, V Mehta, OJ Finn - The Journal of Immunology, 2001 - journals.aai.org
Low-frequency CTL and low-titer IgM responses against tumor-associated Ag MUC1 are
present in cancer patients but do not prevent cancer growth. Boosting MUC1-specific …
present in cancer patients but do not prevent cancer growth. Boosting MUC1-specific …
Tolerance and immunity to MUC1 in a human MUC1 transgenic murine model
GJ Rowse, RM Tempero, ML VanLith… - Cancer research, 1998 - AACR
The human epithelial mucin, MUC1, is a large transmembrane glycoprotein that is
expressed on most simple epithelia. It is overexpressed and aberrantly glycosylated on …
expressed on most simple epithelia. It is overexpressed and aberrantly glycosylated on …
Retargeting of human T cells to tumor-associated MUC1: the evolution of a chimeric antigen receptor
S Wilkie, G Picco, J Foster, DM Davies… - The Journal of …, 2008 - journals.aai.org
MUC1 is a highly attractive immunotherapeutic target owing to increased expression, altered
glycosylation, and loss of polarity in> 80% of human cancers. To exploit this, we have …
glycosylation, and loss of polarity in> 80% of human cancers. To exploit this, we have …
Tumor-specific immunity in MUC1. Tg mice induced by immunization with peptide vaccines from the cytoplasmic tail of CD227 (MUC1)
KG Kohlgraf, AJ Gawron, M Higashi, ML VanLith… - Cancer Immunology …, 2004 - Springer
Abstract Purpose: CD227 (MUC1), a membrane-associated glycoprotein expressed by
many types of ductal epithelia, including pancreas, breast, lung, and gastrointestinal tract, is …
many types of ductal epithelia, including pancreas, breast, lung, and gastrointestinal tract, is …
Human tumor antigen MUC1 is chemotactic for immature dendritic cells and elicits maturation but does not promote Th1 type immunity
CA Carlos, HF Dong, OM Howard… - The Journal of …, 2005 - journals.aai.org
The immunostimulatory outcome of the interactions of many pathogens with dendritic cells
(DCs) has been well characterized. There are many fewer examples of similar interactions …
(DCs) has been well characterized. There are many fewer examples of similar interactions …