The adult human heart does not regenerate significant amounts of lost tissue after injury.
Rather than making new, functional muscle, human hearts are prone to scarring and …

The newt and the zebrafish have the ability to regenerate many of their tissues and organs
including the heart. Thus, a major goal in experimental medicine is to elucidate the …

Efficient cardiac regeneration is closely associated with the ability of cardiac myocytes to
proliferate. Fetal or neonatal mouse hearts containing proliferating cardiac myocytes …

The adult human heart is an ideal target for regenerative intervention since it does not
functionally restore itself after injury yet has a modest regenerative capacity that could be …

Cardiomyocyte proliferation and progenitor differentiation are endogenous mechanisms of
myocardial development. Cardiomyocytes continue to proliferate in mammals for part of post …

The human heart does not regenerate. Instead, following injury, human hearts scar. The loss
of contractile tissue contributes significantly to morbidity and mortality. In contrast to humans …

Adult mammals undergo minimal regeneration following cardiac injury, which severely
compromises cardiac function and contributes to the ongoing burden of heart failure. In …

Circulation. 2017; 136: 680–686. DOI: 10.1161/CIRCULATIONAHA. 117.029343 August 15,
2017 681 proliferation. 5 It remains unclear whether this regenerative window exists in large …

The heart holds the monumental yet monotonous task of maintaining circulation. Although
cardiac function is critical to other organs and to life itself, mammals are not equipped with …

Background It has long been thought that mammalian cardiomyocytes are terminally-
differentiated and unable to proliferate. However, myocytes in more primitive animals such …