Peripheral and lung resident memory T cell responses against SARS-CoV-2

J Grau-Expósito, N Sánchez-Gaona, N Massana… - Nature …, 2021 - nature.com
Resident memory T cells (TRM) positioned within the respiratory tract are probably required
to limit SARS-CoV-2 spread and COVID-19. Importantly, TRM are mostly non-recirculating …

SARS-CoV-2-specific T cell memory is sustained in COVID-19 convalescent patients for 10 months with successful development of stem cell-like memory T cells

JH Jung, MS Rha, M Sa, HK Choi, JH Jeon… - Nature …, 2021 - nature.com
Memory T cells contribute to rapid viral clearance during re-infection, but the longevity and
differentiation of SARS-CoV-2-specific memory T cells remain unclear. Here we conduct ex …

Limited induction of polyfunctional lung-resident memory T cells against SARS-CoV-2 by mRNA vaccination compared to infection

DKJ Pieren, SG Kuguel, J Rosado, AG Robles… - Nature …, 2023 - nature.com
Resident memory T cells (TRM) present at the respiratory tract may be essential to enhance
early SARS-CoV-2 viral clearance, thus limiting viral infection and disease. While long-term …

Unique properties of tissue-resident memory T cells in the lungs: implications for COVID-19 and other respiratory diseases

FR Carbone - Nature Reviews Immunology, 2023 - nature.com
Tissue-resident memory T (TRM) cells were originally identified as a tissue-sequestered
population of memory T cells that show lifelong persistence in non-lymphoid organs. That …

Exposure to SARS-CoV-2 generates T-cell memory in the absence of a detectable viral infection

Z Wang, X Yang, J Zhong, Y Zhou, Z Tang… - Nature …, 2021 - nature.com
T-cell immunity is important for recovery from COVID-19 and provides heightened immunity
for re-infection. However, little is known about the SARS-CoV-2-specific T-cell immunity in …

SARS-CoV-2 infection generates tissue-localized immunological memory in humans

MML Poon, K Rybkina, Y Kato, M Kubota… - Science …, 2021 - science.org
Adaptive immune responses to SARS-CoV-2 infection have been extensively characterized
in blood; however, most functions of protective immunity must be accomplished in tissues …

[PDF][PDF] Robust T cell immunity in convalescent individuals with asymptomatic or mild COVID-19

T Sekine, A Perez-Potti, O Rivera-Ballesteros, K Strålin… - Cell, 2020 - cell.com
Summary SARS-CoV-2-specific memory T cells will likely prove critical for long-term immune
protection against COVID-19. Here, we systematically mapped the functional and …

[PDF][PDF] T cell memory: understanding COVID-19

NN Jarjour, D Masopust, SC Jameson - Immunity, 2021 - cell.com
As the SARS-CoV-2 pandemic has progressed, increasing attention has focused on
establishing natural and vaccine-induced immunity against this coronavirus and the …

Identification of resident memory CD8+ T cells with functional specificity for SARS-CoV-2 in unexposed oropharyngeal lymphoid tissue

J Niessl, T Sekine, J Lange, V Konya, M Forkel… - Science …, 2021 - science.org
Cross-reactive CD4+ T cells that recognize severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) are more commonly detected in the peripheral blood of unexposed …

Tissue‐resident memory T cells and lung immunopathology

IS Cheon, YM Son, J Sun - Immunological Reviews, 2023 - Wiley Online Library
Rapid reaction to microbes invading mucosal tissues is key to protect the host against
disease. Respiratory tissue‐resident memory T (TRM) cells provide superior immunity …