Background Pain is reported as the leading cause of disability in the common forms of
inflammatory arthritis conditions. Acting as a key player in nociceptive processing …

Chemokines and their receptors have been demonstrated to be important contributors to the
development and maintenance of chronic pain. Recent studies showed that chemokine …

Neuropathic pain resulting from peripheral nerve injury involves many persistent
neuroinflammatory processes including inflammatory chemokines that control leukocyte …

Neuropathic pain is a serious clinical issue, and its treatment remains a challenge in
contemporary medicine. Thus, dynamic development in the area of animal and clinical …

Osteoarthritis is one of the leading causes of chronic pain, but almost nothing is known
about the mechanisms and molecules that mediate osteoarthritis-associated joint pain …

A growing body of evidence has indicated that the release of nociceptive factors, such as
interleukins and chemokines, by activated immune and glial cells has crucial significance for …

Previous studies have shown that CCL2 (C–C motif chemokine ligand 2) induces chronic
pain, but the exact mechanisms are still unknown. Here, we established models to explore …

Cytokines such as interleukins are known to be involved in the development of neuropathic
pain through activation of neuroglia. However, the role of chemokine (CC motif) ligand 1 …

CCL2 chemokine and its receptor CCR2 may contribute to neuropathic pain development.
We tested the hypothesis that injury to peripheral nerves triggers CCL2 release from …

Cytokines and chemokines are involved in chronic pain syndromes, and their expression is
altered in injury-induced neuronal pain pathways. However, the exact cytokines/chemokines …