[HTML][HTML] Chronic oxidative stress adaptation in head and neck cancer cells generates slow-cyclers with decreased tumour growth in vivo
J Berner, L Miebach, M Kordt, C Seebauer… - British journal of …, 2023 - nature.com
Background Reactive oxygen species (ROS) are implicated in cancer therapy and as drivers
of microenvironmental tumour cell adaptations. Medical gas plasma is a multi-ROS …
of microenvironmental tumour cell adaptations. Medical gas plasma is a multi-ROS …
Modulators of redox metabolism in head and neck cancer
X Chen, J Mims, X Huang, N Singh… - Antioxidants & Redox …, 2018 - liebertpub.com
Significance: Head and neck squamous cell cancer (HNSCC) is a complex disease
characterized by high genetic and metabolic heterogeneity. Radiation therapy (RT) alone or …
characterized by high genetic and metabolic heterogeneity. Radiation therapy (RT) alone or …
[HTML][HTML] Harnessing oxidative stress as an innovative target for cancer therapy
L Postovit, C Widmann, P Huang… - Oxidative medicine and …, 2018 - ncbi.nlm.nih.gov
One of the hallmarks of cancer is the deregulation of cellular energetics [1]. This allows
cancer cells to proliferate and survive in microenvironments that would lead to the death of a …
cancer cells to proliferate and survive in microenvironments that would lead to the death of a …
[HTML][HTML] Activation of AKT by hypoxia: a potential target for hypoxic tumors of the head and neck
H Stegeman, JH Kaanders, DL Wheeler… - BMC cancer, 2012 - Springer
Background Only a minority of cancer patients benefits from the combination of EGFR-
inhibition and radiotherapy in head and neck squamous cell carcinoma (HNSCC). A …
inhibition and radiotherapy in head and neck squamous cell carcinoma (HNSCC). A …
The tumor microenvironment: characterization, redox considerations, and novel approaches for reactive oxygen species-targeted gene therapy
LL Policastro, IL Ibañez, C Notcovich… - Antioxidants & redox …, 2013 - liebertpub.com
The tumor microenvironment is a complex system that involves the interaction between
malignant and neighbor stromal cells embedded in a mesh of extracellular matrix (ECM) …
malignant and neighbor stromal cells embedded in a mesh of extracellular matrix (ECM) …
[HTML][HTML] Exploring novel strategies to improve anti-tumour efficiency: The potential for targeting reactive oxygen species
RS Chasara, TO Ajayi, DM Leshilo, MS Poka, BA Witika - Heliyon, 2023 - cell.com
The cellular milieu in which malignant growths or cancer stem cells reside is known as the
tumour microenvironment (TME). It is the consequence of the interactivity amongst malignant …
tumour microenvironment (TME). It is the consequence of the interactivity amongst malignant …
Distinct subpopulations of head and neck cancer cells with different levels of intracellular reactive oxygen species exhibit diverse stemness, proliferation, and …
CW Chang, YS Chen, SH Chou, CL Han, YJ Chen… - Cancer research, 2014 - AACR
Head and neck squamous cell carcinoma (HNSCC) is driven by cancer-initiating cells (CIC),
but their maintenance mechanisms are obscure. For hematopoietic stem cells, low levels of …
but their maintenance mechanisms are obscure. For hematopoietic stem cells, low levels of …
HIF-2α-mediated activation of the epidermal growth factor receptor potentiates head and neck cancer cell migration in response to hypoxia
X Wang, A Schneider - Carcinogenesis, 2010 - academic.oup.com
Despite their individual key roles in promoting head and neck squamous cell carcinoma
(HNSCC) progression and treatment resistance, little is known about the impact of …
(HNSCC) progression and treatment resistance, little is known about the impact of …
[HTML][HTML] Oxidative stress in the tumor microenvironment and its relevance to cancer immunotherapy
NS Aboelella, C Brandle, T Kim, ZC Ding, G Zhou - Cancers, 2021 - mdpi.com
Simple Summary Cancer cells are consistently under oxidative stress, as reflected by
elevated basal level of reactive oxygen species (ROS), due to increased metabolism driven …
elevated basal level of reactive oxygen species (ROS), due to increased metabolism driven …
[HTML][HTML] Targeting stress-response pathways and therapeutic resistance in head and neck cancer
T Bos, JA Ratti, H Harada - Frontiers in Oral Health, 2021 - frontiersin.org
Head and neck cancer is the sixth leading cancer worldwide; head and neck squamous cell
carcinoma (HNSCC) accounts for more than 90% of incident cases. In the US, cases of …
carcinoma (HNSCC) accounts for more than 90% of incident cases. In the US, cases of …