Successfully engineering a functional, human, myocardial pump would represent a
therapeutic alternative for the millions of patients with end-stage heart disease and provide …

Cardiac tissue engineering aims to create functional tissue constructs that can reestablish
the structure and function of injured myocardium. Engineered constructs can also serve as …

Cardiovascular disease is a leading cause of death in the US and many countries
worldwide. Current cell-based clinical trials to restore cardiomyocyte (CM) health by local …

Abstract Purpose of Review Bioengineering of functional cardiac tissue composed of
primary cardiomyocytes has great potential for myocardial regeneration and in vitro tissue …

The engineering of 3-dimensional (3D) heart muscles has undergone exciting progress for
the past decade. Profound advances in human stem cell biology and technology, tissue …

Cardiac tissue engineering has emerged as a promising approach to replace or support an
infarcted cardiac tissue and thus may hold a great potential to treat and save the lives of …

Cardiovascular disease is the number one killer worldwide, with myocardial infarction (MI)
responsible for approximately 1 in 6 deaths. The lack of endogenous regenerative capacity …

The ability of human pluripotent stem cells to form all cells of the body has provided many
opportunities to study disease and produce cells that can be used for therapy in …

Whole-organ decellularization has opened the gates to the creation of 3D extracellular
matrix (ECM) templates that mimic nature's design to a degree that—as for today—is not …

Cardiac tissue engineering promises to revolutionize the treatment of patients with end‐
stage heart failure and provide new solutions to the serious problem of heart donor …