Recent molecular classification of glioblastoma (GBM) has shown that patients with a
mesenchymal (MES) gene expression signature exhibit poor overall survival and treatment …

The TAZ transcription co-activator has been shown to promote cell proliferation and to
induce epithelial-mesenchymal transition. Recently we have demonstrated that TAZ is …

TAZ is a WW domain containing a transcription coactivator that modulates mesenchymal
differentiation and development of multiple organs. In this study, we show that TAZ is …

Abstract Purpose: Glioblastomas (GBMs), neoplasms derived from glia and neuroglial
progenitor cells, are the most common and lethal malignant primary brain tumors diagnosed …

Abstract TAZ (WWTR1) and YAP are transcriptional coactivators and oncoproteins inhibited
by the Hippo pathway. Herein we evaluate 159 sarcomas representing the most prevalent …

The evolution of a solid tumor is fueled by genetic aberrations. Yet, the tumor environment
often dominates over the effects of genetics: normal tissues have powerful tumor …

The transcriptional coactivators YAP and TAZ are downstream targets inhibited by the Hippo
tumor suppressor pathway. The expression level of TAZ is recently shown to be elevated in …

Background Glioblastoma (GBM) is a complex disease with extensive molecular and
transcriptional heterogeneity. GBM can be subcategorized into four distinct subtypes; tumors …

Glioblastoma (GBM) is a devastating human malignancy. GBM stem-like cells (GSCs) drive
tumor initiation and progression. Yet the molecular determinants defining GSCs in their …

Transcriptional coactivator with PDZ-binding motif (TAZ) is a transcriptional coactivator
involved in the differentiation of stem cell as well as the development of multiple organs …