Background Navigating the complexities of a severe burn injury is a challenging endeavour
where the natural course of some patients can be difficult to predict. Straddling both the …

Protein C circulates in human plasma to regulate inflammation and coagulation. It has
shown a crucial role in wound healing in animals, and low plasma levels predict the …

Background C-reactive protein (CRP) is an acute-phase protein produced in response to
inflammation after traumatic injury. We posit that C-reactive protein (CRP) is reliable in …

The protein C (PC) pathway plays an important role in vascular function, and acquired
deficiency during sepsis is associated with increased mortality. We have explored the role of …

The protein C system plays an active role in modulating severe systemic inflammatory
processes such as sepsis, trauma, and acute respiratory distress syndrome (ARDS) via its …

Severe burns induce a complex systemic inflammatory response characterized by a typical
prolonged acute phase response (APR) that starts approximately 4–8 h after-burn and …

This is a large cohort analysis in severely burned pediatric children to determine whether C-
reactive protein (CRP) can be used as a predictor for severe infection or sepsis. Nine …

The anticoagulant, activated protein C (aPC), possesses antithrombotic, profibrinolytic, anti-
inflammatory, and antiapoptotic properties, and the level of this protein is an important …

Introduction The inflammatory response to burn injuries can lead to organ dysfunction that
ultimately results in increased mortality and morbidity. This meta-analysis was conducted to …

Despite the success of the anti-coagulant protease protein C (PC) in treating septic shock in
humans, the signaling pathways used are still unclear. To explore the effects of treatment …