The varying efficacy and toxicity of traditional cancer therapies has driven the development
of novel target-based agents. Members of the HER (Human Epidermal Receptor) family, in …

Receptor tyrosine kinases (RTKs) are a superfamily of transmembrane proteins that mediate
intracellular signaling by phosphorylating substrate proteins involved in cell proliferation …

Abstract Learning Objectives After completing this course, the reader will be able to:
Differentiate between ligand-dependent and ligand-independent human epidermal growth …

The epidermal growth factor (EGF) family of receptor tyrosine kinases consists of four
members: EGFR (HER1/ErbB1), HER2/neu (ErbB2), HER3 (ErbB3) and HER4 (ErbB4) …

Molecular inhibition of epidermal growth factor receptor (EGFR/HER1) signaling is under
active investigation as a promising cancer treatment strategy. We examined the potency of …

The epidermal growth factor receptor (EGFR; also referred to as HER1 or ERBB1), is a
member of the type 1 receptor tyrosine kinase family known as the ERBB family. Comprising …

THE EPIDERMAL GROWTH factor receptor (EGFR) is composed of an extra cellular ligand-
binding domain, a transmembrane lipophilic segment, and an intracellular protein kinase …

The epidermal growth factor receptor (EGFR) autocrine pathway contributes to a number of
processes important to cancer development and progression, including cell proliferation …

Human epidermal growth factor receptor (HER)-2 is a member of the HER tyrosine kinase
family, which regulates cell growth and proliferation. HER-2 is overexpressed in 20% to 30 …

Activation of intracellular mitogenic signal transduction pathways driven by the ErbB family
of receptor tyrosine kinases has been implicated in a variety of cancers. Amongst these, the …