Reactive oxygen species (ROS) in macrophage activation and function in diabetes

E Rendra, V Riabov, DM Mossel, T Sevastyanova… - Immunobiology, 2019 - Elsevier
In a diabetic milieu high levels of reactive oxygen species (ROS) are induced. This
contributes to the vascular complications of diabetes. Recent studies have shown that ROS …

Role of reactive oxygen species in the progression of type 2 diabetes and atherosclerosis

H Kaneto, N Katakami, M Matsuhisa… - Mediators of …, 2010 - Wiley Online Library
Type 2 diabetes is the most prevalent and serious metabolic disease all over the world, and
its hallmarks are pancreatic β‐cell dysfunction and insulin resistance. Under diabetic …

Diabetes and vascular disease: pathophysiology, clinical consequences, and medical therapy: part I

F Paneni, JA Beckman, MA Creager… - European heart …, 2013 - academic.oup.com
Hyperglycemia and insulin resistance are key players in the development of atherosclerosis
and its complications. A large body of evidence suggest that metabolic abnormalities cause …

Reactive oxygen species: sources, consequences and targeted therapy in type 2 diabetes

SK Panigrahy, R Bhatt, A Kumar - Journal of drug targeting, 2017 - Taylor & Francis
Oxidative stress has been considered as a central mediator in the progression of diabetic
complication. The intracellular reactive oxygen species (ROS) leads to oxidative stress and it …

Vascular targets of redox signalling in diabetes mellitus

MM Spitaler, WF Graier - Diabetologia, 2002 - Springer
There is overwhelming evidence for an involvement of reactive oxygen species (ROS) in the
pathogenesis of diabetes-associated vascular complications. However, neither the exact …

[HTML][HTML] New insights into oxidative stress and inflammation during diabetes mellitus-accelerated atherosclerosis

T Yuan, T Yang, H Chen, D Fu, Y Hu, J Wang, Q Yuan… - Redox biology, 2019 - Elsevier
Oxidative stress and inflammation interact in the development of diabetic atherosclerosis.
Intracellular hyperglycemia promotes production of mitochondrial reactive oxygen species …

Oxidative stress in neutrophils: implications for diabetic cardiovascular complications

J Johnson, RM Jaggers, S Gopalkrishna… - Antioxidants & redox …, 2022 - liebertpub.com
Significance: Neutrophil behavior and function are altered by hyperglycemia associated with
diabetes. Aberrant activation by hyperglycemia causes neutrophils to respond with …

Oxidative stress and redox modulation potential in type 1 diabetes

MM Delmastro, JD Piganelli - Journal of Immunology Research, 2011 - Wiley Online Library
Redox reactions are imperative to preserving cellular metabolism yet must be strictly
regulated. Imbalances between reactive oxygen species (ROS) and antioxidants can initiate …

[HTML][HTML] Molecular mechanisms of tumor necrosis factor α gene expression in monocytic cells via hyperglycemia-induced oxidant stress-dependent and-independent …

M Guha, W Bai, JL Nadler, R Natarajan - Journal of Biological Chemistry, 2000 - ASBMB
Increased oxidative stress has been reported in vivo in the diabetic state via the production
of reactive oxygen species (ROS). Such stress is bound to play a key role on activation of …

A review on cellular and molecular mechanisms linked to the development of diabetes complications

RA Babel, MP Dandekar - Current Diabetes Reviews, 2021 - ingentaconnect.com
Modern lifestyle, changing eating habits and reduced physical work have been known to
culminate into making diabetes a global pandemic. Hyperglycemia during the course of …