There is a growing interest on the role of autophagy in diabetes pathophysiology, where
development of neuropathy is one of the most frequent comorbidities. We have previously …

Significance: The prevalence of metabolic syndrome (MetS) and associated obesity has
increased in recent years, affecting millions worldwide. One of the most common …

Caloric restriction (CR) slows the aging process, extends lifespan, and exerts
neuroprotective effects. It is widely accepted that CR attenuates β-amyloid (Aβ) …

Peripheral neuropathy (PN) is a severe complication that affects over 30% of prediabetic
and 60% of type 2 diabetic (T2D) patients. The metabolic syndrome is increasingly …

Background Severe calorie restriction (CR) is shown to improve or even reverse β-cell
dysfunction in patients with obesity and type 2 diabetes mellitus. However, whether mild to …

Anorexia nervosa (AN) is an eating disorder leading to malnutrition and, ultimately, to
energy wasting and cachexia. Rodents develop activity-based anorexia (ABA) when …

This study focused on the relationship between extracellular-regulated kinase (ERK) and
obesity-induced increases in neuropathic pain. We fed rats a high-fat diet to establish the …

High-caloric diet and physical inactivity predispose individuals to obesity and diabetes,
which are risk factors of hippocampal neurodegeneration and cognitive deficits. Along with …

Painful diabetic neuropathy is a common complication of diabetes mellitus with obscure
underlying mechanisms. The adaptor protein APPL1 is critical in mediating the insulin …

Axonal degeneration in peripheral nerves after injury is accompanied by myelin degradation
initiated by Schwann cells (SCs). These cells activate autophagy, a ubiquitous cytoprotective …