Pharmacologic targeting of hypoxia-inducible factors
GL Semenza - Annual review of pharmacology and toxicology, 2019 - annualreviews.org
Hypoxia-inducible factors (HIFs) control transcriptional responses to reduced O2 availability.
HIFs are heterodimeric proteins composed of an O2-regulated HIF-α subunit and a …
HIFs are heterodimeric proteins composed of an O2-regulated HIF-α subunit and a …
The role of hypoxia-inducible factors in metabolic diseases
FJ Gonzalez, C Xie, C Jiang - Nature Reviews Endocrinology, 2019 - nature.com
Abstract Hypoxia-inducible factors (HIFs), a family of transcription factors activated by
hypoxia, consist of three α-subunits (HIF1α, HIF2α and HIF3α) and one β-subunit (HIF1β) …
hypoxia, consist of three α-subunits (HIF1α, HIF2α and HIF3α) and one β-subunit (HIF1β) …
[HTML][HTML] Expression of hypoxia-inducible factor 1: mechanisms and consequences
GL Semenza - Biochemical pharmacology, 2000 - Elsevier
Hypoxia-inducible factor 1 (HIF-1) is a basic-helix-loop-helix transcription factor that plays
essential roles in mammalian development and physiology. HIF-1 is a heterodimer …
essential roles in mammalian development and physiology. HIF-1 is a heterodimer …
Signal transduction to hypoxia-inducible factor 1
GL Semenza - Biochemical pharmacology, 2002 - Elsevier
Hypoxia-inducible factor 1 (HIF-1) is a transcriptional activator that functions as a master
regulator of O2 homeostasis. HIF-1 target genes encode proteins that increase O2 delivery …
regulator of O2 homeostasis. HIF-1 target genes encode proteins that increase O2 delivery …
Regulatory mechanisms of hypoxia‐inducible factor 1 activity: Two decades of knowledge
Hypoxia‐inducible factor 1 (HIF‐1) is a transcriptional activator of various genes related to
cellular adaptive responses to hypoxia. Dysfunctions in the regulatory systems of HIF‐1 …
cellular adaptive responses to hypoxia. Dysfunctions in the regulatory systems of HIF‐1 …
Modulating the hypoxia-inducible factor signaling pathway: applications from cardiovascular disease to cancer
KS Hewitson, LA McNeill… - Current pharmaceutical …, 2004 - ingentaconnect.com
Humans, like other complex aerobic organisms, possess highly evolved systems for the
delivery of dioxygen to all the cells of the body. These systems are regulated since …
delivery of dioxygen to all the cells of the body. These systems are regulated since …
[HTML][HTML] Regulation of gene expression by the hypoxia-inducible factors
AO Fedele, ML Whitelaw… - Molecular …, 2002 - triggered.stanford.clockss.org
Many molecular and physiological responses to hypoxia in mammals are controlled by the
transcription factors Hypoxia-Inducible Factor-1α (HIF-1α) and HIF-2α. Their ability to …
transcription factors Hypoxia-Inducible Factor-1α (HIF-1α) and HIF-2α. Their ability to …
Hydroxylation of hypoxia-inducible transcription factors and chemical compounds targeting the HIF-α hydroxylases
K Bruegge, W Jelkmann… - Current medicinal …, 2007 - ingentaconnect.com
The hypoxia-inducible transcription factors (HIFs) are central components in the cellular
responses to a lack of O2, ie hypoxia. Homologs of the HIF system (HIF-1,-2 and-3) are …
responses to a lack of O2, ie hypoxia. Homologs of the HIF system (HIF-1,-2 and-3) are …
Hypoxia‐inducible factor 1 and cancer pathogenesis
GL Semenza - IUBMB life, 2008 - Wiley Online Library
Abstract Hypoxia‐inducible factor 1 (HIF‐1) is a transcriptional activator that mediates
adaptive responses to hypoxia. HIF‐1 activity is increased in the majority of human cancers …
adaptive responses to hypoxia. HIF‐1 activity is increased in the majority of human cancers …
Hypoxia-inducible factor-1 (HIF-1)
Q Ke, M Costa - Molecular pharmacology, 2006 - ASPET
Adaptation to low oxygen tension (hypoxia) in cells and tissues leads to the transcriptional
induction of a series of genes that participate in angiogenesis, iron metabolism, glucose …
induction of a series of genes that participate in angiogenesis, iron metabolism, glucose …