OBJECTIVE: Glioblastoma multiforme is a malignant primary brain tumor associated with
short patient survival despite aggressive treatment, in part because of its propensity to …

OBJECTIVE: Amplification of the epidermal growth factor receptor (EGFR) is a common
event in the molecular pathogenesis of high-grade astrocytic tumors, occurring in 50% of …

✓ Rapid growth and diffuse brain infiltration are hallmarks of malignant gliomas. The
underlying molecular pathomechanisms of these tumors, however, remain to be determined …

Abstract Effects of epidermal growth factor (EGF) and an antibody (Ab-528) reactive against
the binding site for EGF on human EGF receptors were studied on multicellular tumor …

OBJECTIVE: Overexpression of epidermal growth factor receptor (EGFR) in glioblastoma
multiforme (GBM) secondary to EGFR gene amplification is associated with a more …

Object. The goal of this study was to determine the effects of SU6668, a polyvalent receptor
tyrosine kinase inhibitor against vascular endothelial growth factor receptor—2, platelet …

Glioblastoma multiforme (GBM) is the most aggressive type of glioma and GBMs frequently
contain amplifications or mutations of the EGFR gene. The most common mutation results in …

Abstract INVADING GLIOMA CELLS seem to follow distinct anatomic structures within the
central nervous system. Tumor cell dissemination may occur along structures, such as the …

Simple Summary The estimated survival time for glioblastoma patients is extremely low; only
about 5% of patients survive five years post diagnosis. The standard of care for glioblastoma …

✓ Our earlier investigations of the biology of the epidermal growth factor receptor (EGFR) in
human gliomas demonstrated that the level of EGFR expression did not directly predict the …