Oridonin: a review of its pharmacology, pharmacokinetics and toxicity

X Li, CT Zhang, W Ma, X Xie, Q Huang - Frontiers in pharmacology, 2021 - frontiersin.org
Oridonin, as a natural terpenoids found in traditional Chinese herbal medicine Isodon
rubescens (Hemsl.) H. Hara, is widely present in numerous Chinese medicine preparations …

Therapeutic potential of oridonin and its analogs: from anticancer and antiinflammation to neuroprotection

J Xu, EA Wold, Y Ding, Q Shen, J Zhou - Molecules, 2018 - mdpi.com
Oridonin, a diterpenoid natural product commonly used in East Asian herbal medicine, is
garnering increased attention in the biomedical community due to its extensive biological …

Solubility and bioavailability enhancement of oridonin: a review

Y Zhang, S Wang, M Dai, J Nai, L Zhu, H Sheng - Molecules, 2020 - mdpi.com
Oridonin (ORI), an ent-kaurene tetracyclic diterpenoid compound, is isolated from Chinese
herb Rabdosia rubescens with various biological and pharmacological activities including …

Molecular insight in the multifunctional effects of oridonin

BA Owona, HJ Schluesener - Drugs in R&D, 2015 - Springer
Oridonin has attracted considerable attention in the last decade because of its anti-cancer
pharmacological properties. This ent-kaurane diterpenoid, isolated from the Chinese herb …

[HTML][HTML] Oridonin and its derivatives for cancer treatment and overcoming therapeutic resistance

X Liu, J Xu, J Zhou, Q Shen - Genes & diseases, 2021 - Elsevier
Cancer is one of the diseases with high morbidity and mortality on a global scale.
Chemotherapy remains the primary treatment option for most cancer patients, including …

Discovery and development of natural product oridonin-inspired anticancer agents

Y Ding, C Ding, N Ye, Z Liu, EA Wold, H Chen… - European journal of …, 2016 - Elsevier
Natural products have historically been, and continue to be, an invaluable source for the
discovery of various therapeutic agents. Oridonin, a natural diterpenoid widely applied in …

[HTML][HTML] Oridonin inhibits oral cancer growth and PI3K/Akt signaling pathway

J Yang, X Ren, L Zhang, Y Li, B Cheng, J Xia - Biomedicine & …, 2018 - Elsevier
Oridonin, a bioactive diterpenoid purified from Rabdosia rubescens, has been shown to
possess anticancer capacity in several cancer types. However, its effects on oral squamous …

Oridonin inhibits vascular inflammation by blocking NF-κB and MAPK activation

W Huang, M Huang, H Ouyang, J Peng… - European journal of …, 2018 - Elsevier
Oridonin, an active diterpenoid compound isolated from the plant Rabdosia Rrubescens,
has various pharmacological activities, including antioxidant, anti-tumor capacities and anti …

Synthesis, and evaluation of in vitro and in vivo anticancer activity of 14-substituted oridonin analogs: A novel and potent cell cycle arrest and apoptosis inducer …

QK Shen, H Deng, SB Wang, YS Tian… - European Journal of …, 2019 - Elsevier
A series of novel oridonin derivatives bearing various substituents on the 14-OH position
were designed and synthesised. Their antitumour activity was evaluated in vitro against …

Oridonin, a Promising ent-Kaurane Diterpenoid Lead Compound

D Li, T Han, J Liao, X Hu, S Xu, K Tian, X Gu… - International Journal of …, 2016 - mdpi.com
Oridonin belongs to ent-kaurane tetracyclic diterpenoid and was first isolated from Isodon
species. It exhibits inhibitory activities against a variety of tumor cells, and pharmacological …