Changes in delta‐9‐tetrahydrocannabinol (THC) and cannabidiol (CBD) concentrations in cannabis over time: systematic review and meta‐analysis

TP Freeman, S Craft, J Wilson, S Stylianou… - …, 2021 - Wiley Online Library
Background and aims Cannabis products with high delta‐9‐tetrahydrocannabinol (THC)
concentrations carry an increased risk of addiction and mental health disorders, while it has …

Increasing delta-9-tetrahydrocannabinol (Δ-9-THC) content in herbal cannabis over time: systematic review and meta-analysis

F Cascini, C Aiello, GL Di Tanna - Current drug abuse reviews, 2012 - ingentaconnect.com
Aim: The objective of this meta-analysis is to assess the data regarding changes in herbal
cannabis potency over time (from 1970 to 2009). Methods: Systematic searches of 17 …

Potency trends of Δ9‐tetrahydrocannabinol, cannabidiol and cannabinol in cannabis in the Netherlands: 2005–15

RJM Niesink, S Rigter, MW Koeter, TM Brunt - Addiction, 2015 - Wiley Online Library
Abstract Background and Aims Between 2000 and 2005 the average percentage of Δ9‐
tetrahydrocannabinol (THC) in marijuana as sold in Dutch coffeeshops has increased …

Potency of Δ9–tetrahydrocannabinol and other cannabinoids in cannabis in England in 2016: Implications for public health and pharmacology

DJ Potter, K Hammond, S Tuffnell… - Drug testing and …, 2018 - Wiley Online Library
In 2005 and 2008, studies reported that cannabis in England had become dominated by the
sinsemilla (unseeded female) form. The average potency (Δ9‐tetrahydrocannabinol [THC] …

A comprehensive review of cannabis potency in the United States in the last decade

MA ElSohly, S Chandra, M Radwan… - Biological Psychiatry …, 2021 - Elsevier
This review examines the concentration of seven major cannabinoids, including Δ 9-
tetrahydrocannabinol (THC) and cannabidiol (CBD), in illicit herbal cannabis products …

Psychiatric symptoms caused by cannabis constituents: a systematic review and meta-analysis

G Hindley, K Beck, F Borgan, CE Ginestet… - The Lancet …, 2020 - thelancet.com
Background Approximately 188 million people use cannabis yearly worldwide, and it has
recently been legalised in 11 US states, Canada, and Uruguay for recreational use. The …

[HTML][HTML] Does cannabidiol make cannabis safer? A randomised, double-blind, cross-over trial of cannabis with four different CBD: THC ratios

A Englund, D Oliver, E Chesney, L Chester… - …, 2023 - nature.com
As countries adopt more permissive cannabis policies, it is increasingly important to identify
strategies that can reduce the harmful effects of cannabis use. This study aimed to determine …

[HTML][HTML] Potency and therapeutic THC and CBD ratios: US cannabis markets overshoot

SD Pennypacker, K Cunnane, MC Cash… - Frontiers in …, 2022 - frontiersin.org
Background and aims: The effects exuded by cannabis are a result of the cannabinoids
trans-Δ⁹-tetrahydrocannabinol (THC) and cannabidiol (CBD), and is dependent upon their …

Assessment of orally administered Δ9-tetrahydrocannabinol when coadministered with cannabidiol on Δ9-tetrahydrocannabinol pharmacokinetics and …

CA Zamarripa, TR Spindle, R Surujunarain… - JAMA Network …, 2023 - jamanetwork.com
Importance Controlled clinical laboratory studies have shown that cannabidiol (CBD) can
sometimes attenuate or exacerbate the effects ofΔ9-tetrahydrocannabinol (Δ9-THC). No …

'Standard THC units': a proposal to standardize dose across all cannabis products and methods of administration

TP Freeman, V Lorenzetti - Addiction, 2020 - Wiley Online Library
Abstract Background and Aims Cannabis products are becoming increasingly diverse, and
vary considerably in concentrations of∆ 9‐tetrahydrocannabinol (THC) and cannabidiol …