Adipokines: a treasure trove for the discovery of biomarkers for metabolic disorders

S Lehr, S Hartwig, H Sell - PROTEOMICS–Clinical Applications, 2012 - Wiley Online Library
Adipose tissue is a major endocrine organ, releasing signaling and mediator proteins,
termed adipokines, via which adipose tissue communicates with other organs. Expansion of …

Identification and validation of novel adipokines released from primary human adipocytes

S Lehr, S Hartwig, D Lamers, S Famulla… - Molecular & cellular …, 2012 - ASBMB
Adipose tissue is a major endocrine organ, releasing signaling and mediator proteins,
termed adipokines, via which adipose tissue communicates with other organs. Expansion of …

Functional annotation of the human fat cell secretome

I Dahlman, M Elsen, N Tennagels, M Korn… - … of physiology and …, 2012 - Taylor & Francis
Contex t: Recent secretome analyses suggest that human fat cells secrete hundreds of
proteins (adipokines). Objective: We made an overall analysis of their potential functional …

Temporal profiling of the secretome during adipogenesis in humans

J Zhong, SA Krawczyk, R Chaerkady… - Journal of proteome …, 2010 - ACS Publications
Adipose tissue plays a key role as a fat-storage depot and as an endocrine organ. Although
mouse adipogenesis has been studied extensively, limited studies have been conducted to …

Characterization of the human visceral adipose tissue secretome

G Alvarez-Llamas, E Szalowska, MP de Vries… - Molecular & Cellular …, 2007 - ASBMB
Adipose tissue is an endocrine organ involved in storage and release of energy but also in
regulation of energy metabolism in other organs via secretion of peptide and protein …

Comparative secretome analyses of primary murine white and brown adipocytes reveal novel adipokines

AA Khan, J Hansson, P Weber, S Foehr… - Molecular & Cellular …, 2018 - ASBMB
The adipose organ, including white and brown adipose tissues, is an important player in
systemic energy homeostasis, storing excess energy in form of lipids while releasing energy …

In-depth analysis of the adipocyte proteome by mass spectrometry and bioinformatics

J Adachi, C Kumar, Y Zhang, M Mann - Molecular & Cellular Proteomics, 2007 - ASBMB
Adipocytes are central players in energy metabolism and the obesity epidemic, yet their
protein composition remains largely unexplored. We investigated the adipocyte proteome by …

Adipokines as novel biomarkers and regulators of the metabolic syndrome

Y Deng, PE Scherer - Annals of the New York Academy of …, 2010 - Wiley Online Library
Over the past two decades our view of adipose tissue has undergone a dramatic change
from an inert energy storage tissue to an active endocrine organ. Adipose tissue …

Adipose tissue as a regulator of energy balance

S Klaus - Current drug targets, 2004 - ingentaconnect.com
Adipose tissue plays an active role in energy balance because it is not only a lipid storing
and mobilizing tissue but consists of functionally specialized tissues able to produce heat (in …

Adipose tissue and adipokines: the association with and application of adipokines in obesity

M Khan, F Joseph - Scientifica, 2014 - Wiley Online Library
2014 marks the 20th anniversary of adipokines. Through the identification of leptin, our
perceived understanding of adipose tissue was changed instantaneously. From a simple …