The oiling out and crystallization behavior of a pharmaceutical compound from acetone and
water was studied using a range of in-situ tools to qualitatively describe the oiling out …

The oiling out and crystallization of a pharmaceutical compound from a water− ethanol
mixture has been studied using a range of in-line process analytical techniques in order to …

A new approach to crystallize oily substances is described. The tendency for liquid–liquid
phase separation (LLPS) is reduced by decreasing the kinetics of self-association via the …

Oiling out during the crystallization process often generates agglomeration. This research is
focused on the control of agglomeration in the antisolvent crystallization of the …

This paper presents and compares crystallization experiments of an active pharmaceutical
ingredient and a biological molecule in the presence of a liquid− liquid phase separation …

In a previous paper (Veesler, S.; Lafferrere, L.; Garcia, E.; Hoff, C. Org. Proc. Res. Dev. 2003,
7, 983), the impact of a liquid− liquid-phase separation (LLPS) or demixing on solution …

The nucleation point of erythromycin ethylsuccinate crystallization with liquid–liquid phase
separation, also called oiling-out, was determined through nucleation analysis. To achieve …

Oiling‐out phenomenon occurs in many crystallization processes and might cause
processing problems especially in the drug crystallization. This paper discusses the …

The oiling out crystallization of a pharmaceutical compound API-T dissolved in
acetone/water was conducted using a 100 mL crystallizer, and the effect of oil droplets on …

Particle size distribution (PSD) is one of the critical attributes of crystals. PSD not only
influences downstream processes but also controls final product performance in …